Clinical Analysis Of 80 Cases Of Systemic Lupus Erythematosus Patients With Pulmonary Infection Etiology Positive

Objective:The objective of our study was to analysis the etiology, laboratory examination and risk factors of Systemic Lupus Erythematosus(SLE) patients with pulmonary infection in the First Affiliated Hospital of Guangxi Medical University.Methods:In this study, a total of 80 SLE patients have a clear etiology with pulmonary infection were recruited in the First Affiliated Hospital of Guangxi Medical University as a case study group. The control group from the same period in hospital 80 cases of SLE with non-infected patients according to 1:1 ratio from the same period of hospitalization in patients with SLE noninfectious stratified random sample, to ensure the two groups of sex, age, duration match. To collected the two group patients’general condition, complications, laboratory examination, etiology, treatment and the cause of death.Results:1. The fatality rate was 23.75%, and infection was the major cause. The major etiology of the infection was the superinfection that was caused by gram-negative bacteria with fungal infection. And the fatality rate of superinfection was 63.2%, mainly to nosocomial infections.2. Ardent fever increased in the SLE patients with infection. And compare to the control subjects, the WBC, absolute neutrophil count,neutrophilic granulocyte percentage, white/lymphocyte ratio,24-hour urine protein, LDH, CRP and ESR increased in the SLE patients with infection. On the other side, level of LYM, HB, ALB and C3 decreased in the SLE patients with infection, compared to the control subjects.3. The correlation analysis showed that the level of WBC and neutrophil count were positively correlation with the SLEDAI score in the SLE patients with infection. SLEDAI score was negatively analysis with the level of LYM. And the level of neutrophil count showed the positively correlation with the level of LDH, CRP in the SLE patients with infection.4. The positive rate of SS-A antibody decreased in the SLE patients with infection. It suggested that SS-A antibody may be the risk factor of the infection of SLE patients.5. The treatment of gamma globulin is effective in the SLE patients with infection. In the intra-group, affected organs≥2 may be the prognosis factor of the SLE patients with infection.In the inter-group analysis, the treatment of immunity inhibitor and the hypoproteinemia may be the influential factors of the infection of SLE patients.Conclusion:1. The major pathogens of the secondary infection of the SLE patients were gram-negative bacteria, and most of them showed as nosocomial infection.2.SLE patients likely exposured to lung infection iin the first year of the duration.3.The application of immune inhibitor may be the risk factor of the SLE patients with secondary infection.4.Combined with multiple organ involvement, the prognosis of the SLE patients with secondary infection became worse.