Study Of The Expression Of Cyclin E1 In Epithelial Ovarian Tumors

Objective: Ovarian cancer is a common malignant tumor in women, with higher mortality rate.There are 2.2 million women occurring epithelial ovarian cancer each year worldwide. In the UK, every year 7000 women suffering from ovarian cancer(4200 patients die each year); In the United States, 22,500 women suffering from ovarian cancer(14,000 deaths annually death) each year. 67% of the patients were diagnosed with advanced epithelial ovarian cancer with poor prognosis. Higher level of expression of protein E has a relationship with the progress of human cancers, particularly breast cancer, further comprising leukemia, lymphoma, and other types of tumors. In the transgenic mouse model, the higher expression of cyclin E1 promote the development of malignant diseases, thus considered as carcinogenic cyclin E1 protein. In this study, we study the expression of cyclin E1 in epithelial ovarian tumors, and explore the relationship between cyclin E1 and epithelial ovarian cancer.Methods: We collect information about ovarian disease patients of Obstetrics of Fourth Hospital of Hebei Medical University from January 2014 to January 2015, normal ovarian patients is 20, benign ovarian epithelial tumors patients is 20, epithelial ovarian cancer patients is 60. The experimental group divided by different aspects:1 all patients were divided into two groups by 55 years old; 2 divided into two groups by body mass index(BMI) 30 kg / m2; 3 divided into normal ovarian tissue(A), benign epithelial ovarian tumors(B), epithelial ovarian cancer(C), including Normal group, Control group, Cancer group; 4 all epithelial ovarian cancer patients is divided into I, II, III, IV period; All benign and malignant disease confirmed by pathology, distant metastasis in patients with pathologically confirmed through a hollow needle to obtain, or pleural effusion cytology detected cancer cells. Immunohistochemical SP method to detect different groups of patients with ovarian cancer tissue cyclin E1. Application of SPSS 13.0 statistical software for two sample size and diversity of the amount of the X2 test to a = 0.05 level for the test.Results:1 The statistics, three samples of the patient in terms of age was not statistically significant(P = 0.135), patients with normal ovaries was 54.8±9.0 years old, benign epithelial ovarian cancer patient was 54.9±7.1 years, epithelial ovarian cancer patients was 55.5±6.2 years.2 This study in patients with epithelial ovarian cancer were divided into two age groups, and the expression of cyclin E1≦55 years old, 25 people expressing their cyclin E1 was 127.41±15.36, >55, there are 35 people expressing cyclin E1 was 119.58±13.83, P=0.157.3 Normal ovaries(A) tissue of patients with a BMI of 24.12±3.47, benign epithelial ovarian tumors(B) patients with a BMI of 24.34±3.22, epithelial ovarian cancer(C) in patients with a BMI of 25.75±5.21, three groups of patients in the sample have a BMI statistically significant(P= 0.072).4 60 cases of epithelial ovarian cancer. Among obese patients(BMI≥30 kg / m2) Number of 39 people, non-obese patients(BMI<30kg / m2) for 21 people, and the expression of cyclin E1 obese patients was 103.41±18.91, cell cycle non-obese patients E1 protein expression was 131.25 ± 15.35(P=0.012).5 Measurement of normal ovarian tissue(A), benign epithelial ovarian tumors(B), the expression of the cell cycle of ovarian cancer(C) organization E1 protein, in turn increased, respectively 197.42±12.59, 165.56±15.48, 120.45±18.73. Comparison between the two for A and B, P = 0.025; A and C, P = 0.000; B and C, P = 0.000.6 Patients with epithelial ovarian cancer, all patients were divided into I, II, III, IV stage, the expression of cyclin E1 in I, II, III, IV stage, in turn increased, respectively 147.42±8.13, 132.56±16.46,103.59±11.06, 80.36±9.54,P = 0.000; I and II, P = 0.121; I and III, P = 0.000; I and IV, P = 0.000; II and III, P = 0.004; II and IV, P = 0.000; III and IV, P = 0.037.Conclusions:1 Obesity is a risk factor for ovarian cancer incidence in obese patients.2 Cyclin E1 expression higger in obese epithelial ovarian carcinoma, suggesting that obesity may be a risk factor to promote development of epithelial ovarian cancer.3 Cyclin E1 expression was significantly higher in epithelial ovarian carcinoma, suggesting that cyclin E1 can promote the occurrence of epithelial ovarian cancer.4 Cyclin E1 expression was significantly higher in patients with advanced epithelial ovarian cancer, suggesting that cyclin E1 may contribute to the development of epithelial ovarian cancer.