The Investigation And Analysis Of Anticoagulation In Huangpu District Inpatients With Non-valvular Atrial Fibrillation

Objective: To investigate and analyze the factors of the antithrombotictherapy in inpatients with non-valvular atrial fibrillation (AF) in HuangpuDistrict and provide a basis for further regulate antithrombotic therapy.Methods: A survey of inpatients with non-valvular atrial fibrillation fromJanuary2010to December2013in Hospital of Huangpu District, by fillingout the questionnaire, recording disease characteristics of the patients,comorbidities and antithrombotic drug use, using CHADS2scoreassessment to assess the risk of thromboembolism in patients with atrialfibrillation, using HAS-BLED score to assess patients of the risk of bleedingand using logistic regression to analysis influencing factors for warfarin.Result: All enrolled457patients with non-valvular atrial fibrillation,male224cases (49%), female233cases (51%)，115patients (25.1%) arelong-term smokers,30patients (6.6%) are long-term drinking,347patients(75.9%) with hypertension,228patients (49.9%) with chronic heart failure,265patients (57.9%) with stroke/TIA,123patients (26.9%) with diabetes,333patients(72.9%) with hyperlipidemia.7patients (1.5%) of the allatrial fibrillation patients had a CHADS2score=0,55patients (12%) had aCHADS2score=1and395patients (86.5%) had a CHADS2score≥2 points.261patients (57.1%) with atrial fibrillation had a HAS-BLED score≤2and196patients (42.9%)had a HAS-BLED score≥3.28patients (6.1%)with atrial fibrillation do not take antithrombotic drugs,326patients (71.3%)take aspirin,103patients (22.6%) take warfarin.Among395patients whohad CHADS2score≥2,85patients(21.5%) take warfarin, aspirin has289patients(73.2%) take aspirin,21patients (5.3%) do not take anyantithrombotic drugs.2patients (0.4%) who take warfarin have a bleedingevent,19patients (4.2%) who take warfarin have a bleeding event,25cases(5.4%) who has a HAS-BLED score≥3points have a bleeding event. Inmultivariate regression analysis, age factor affecting the use of warfarin,elderly patients with atrial fibrillation warfarin use grossly inadequate.Conclusion:The antithrombotic therapy is low in the hospitalized patientswith non-valvular atrial fibrillation in Huangpu District. The reason may beassociated with assessment inadequate in risk of thromboembolism,bleeding risk and excessive concerns about drug side effects, while takewarfarin is particularly poor among the elderly patients.