Change Of Dendroaspis Natriuretic Peptide(DNP) Contents In The Plasma Of Coronary Atherosclerotic Heart Disease

ObjectiveTo investigate the change of plasma dendroaspis natriuretic peptide(DNP) levelsin coronary heart disease (CHD) and to explore the possible role of DNP during itsdevelopment.MethodsPatients admitted to Fujian Medical University Union Hospital because of chestpain and underwent the coronary angiography was selected from July,2013toApril,2014. All selected cases were divided into the group of CHD and thecontrol group according to the results of coronary angiography. Then the CHD groupwas divided into stable angina(SA) group, unstable angina(UA) group and the acutemyocardial infarction(AMI) group, in each case, the Gensini score wascalculated according to the result of coronary angiography to quantify the severity ofcoronary lesion. Plasma DNP, cGMP and NEP concentration was measured byenzyme linked immunosorbent assay(ELISA).Results48patients with CHD met the inclusion criteria were enrolled, including stableangina9cases, unstable angina26cases, acute myocardial infarction13cases;45non-CHD patients were enrolled as control group. The level of plasma DNP inCHD group (5060±1870pg/mL) was higher than that in controlgroup (4250±1270pg/mL), the difference was significant (p<0.05). There was nodifference in plasma cGMP（75.79±25.33nmol/L vs69.88±23.00nmol/L）and NEP（143.97±53.39ng/mL vs138.30±55.76ng/mL）concentration between the twogroup(p>0.05). There was no difference in DNP concentration between different typesof CHD group (p>0.05). There was no significant correlation between theconcentration of plasma DNP and Gensini score after pearson correlation test （r=0.105）. Set CHD as dependent variable and DNP, log NT-proBNP, log hs-CRP,LVEF as independent variable, logistic regression analysis revealed that: DNP,NT-proBNP and hs-CRP was positively correlated with the positive rate of CHD（βDNP=0.737,Exp (βDNP)=2.090, βNT-proBNP=1.875,Exp (βNT-proBNP)=6.523, βhs-CRP=1.892,Exp (βhs-CRP)=6.630）, and LVEF values was negatively correlated withthe positive rate of CHD（β=-0.092,Exp (β)=0.912）.ConclusionsThe present study demonstrated that the plasma DNP was higher in patients withCHD, it may play a role in the development of CHD.