Prognosis Analysis Of Advanced Pancreatic Cancer Of92Cases Of Patients With Palliative Surgery

Objective:Study the Clinical Features of advanced pancreatic cancer patients with palliative surgery, analysis of different palliative surgical procedures of the prognostic impact on the patients, to guide the treatment of advanced pancreatic cancer palliative surgery. Methods:Retrospectively reviewed105advanced pancreatic cancer patients with Palliative surgery from January2005to December2011, follow-up by telephone and back to hospital review,92cases were followed up, according to the operative method, divide the patients to4groups, namely biliary enteric anastomosis group, biliary enteric anastomosis+gastroenterostomy group, common bile duct stenting group, biliary tract external drainage group, Compare postoperative survive period、symptom remission、 operative complications of the four group, statistically analyzed by EXCEL2010and SPSS17.0. Results:This group of patients with advanced pancreatic cancer, the median survival time was148days; The survival difference of thefour kinds of surgical was statistically significant (x2=17.851, P<0.001), compared with other surgical group, the median survival time (164days) of biliary enteric anastomosis+gastroenterostomy group was longer, the survival rate was higher. By COX multivariate analysis, surgical, surgical complications and age had influence on survival time. By repeated measures analysis of variance showed, the effect of reducing jaundice of the four kinds of surgery was no significant difference (P>0.05), For improving the nutritional status of patients using albumin as an indicator, ompared with other surgical, albumin of biliary enteric anastomosis+gastroenterostomy group had significantly increased, one and three month after operation was higher than other surgical methods (P<0.001). Conclusion:The biliary enteric anastomosis+gastroenterostomy group was better than other group in extending the median survival time, bilirubin subsided, nutrition improvement, For patients with advanced pancreatic cancer who has lost the opportunity to be implemented should be early accepted biliary enteric anastomosis+gastroenterostomy, Such as patients with poor general condition and intra-hepatic bile duct dilation does not allow implementation of open surgery can implemente percutaneous transhepatic puncture or Endoscopic drainage of the common bile duct stent, Try to avoid Simple biliary reconstruction、Simple digestive tract reconstruction and External biliary drainage surgery.