Molecular Subtypes And Prognosis Between Uyghur And Han Patients With Breast Cancer

Objective:To study the difference in constituent ratio of molecular typing in breast cancer tissue and in histological typing between Uyghur and Han female patients, and to analyze the correlation between molecular typing and prognosis in patients with breast cancer in two ethnicities living in the same region. Methods:307inpatients, with83Uyghur and224Han, who were admitted to hospital during January2001to December2008in the first affiliated hospital of Xinjiang medical university, were tested by Immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH). All patients were divided into four molecular typing:Luminal A, Luminal B, HER-2Overexpression and Basal-like. The clinical feature and prognosis of breast cancer with one of above molecular typing in two ethnicities were analyzed too. Results:There was significant difference in constituent ratio of clinical stage between Uyghur and Han groups.(x1=8.304, P=0.016). There was no statistically significant difference in constituent ratio of pathological classification, molecular typing and ER/PR/HER-2/Ki-67expression in breast tumor cells(Ps>0.05) between Uyghur and Han groups.271cases among307were followed up completely, and the drop-out rate was11.73%. Univariate analysis with Kaplan-Meier method showed that there was statistically significant difference in disease-free survival(DFS) according to different factors, such as nationality, clinical staging, PR, primary tumor size, lymph node metastasis and molecular typing (Ps<0.05), but there was no significant difference in that of age, histological typing, ER, HER-2and Ki-67(P5>0.05). Multi-factors Cox regression analysis showed that only lymph node metastasis and molecular typing were risk indicators which could predict the prognosis of breast cancer. Conclusion:There was no significant difference in the constituent ratio of molecular typing of breast cancer between Uyghur and Han patients, but there was significant difference in the clinical feature between two ethnicities; Lynph noed metastasis and molecular subtypes can be choosed to the prognostic indicator of breast cancer and provide guidance for the clinical therapy.