The Clinical Case Analysis Of Neonatal Hypoglycemia And Brain Injury

Objective:To discuss dangerous factors of neonatus with recurrenthypoglycemia， moreover， to analyse the risk factors and clincalcharacteristics among newborns with brain injury caused by hypoglycemia.Methods:Retrospective analysis of the clinical datas in neonatus ofhypoglycemia and newborns of diabetic mother.Those datas can be dividedinto experiment-control groups according to different classifications:1.Transient hypoglycemia and hypoglycemia occured repeatedly groups.2.hypoglycemia brain injury（HBI）group and non-hypoglycemia braininjury（NHBI）group.3.Hypoglycemia and non-hypoglycemia in infant of diabetes mother，Three groups were analyzed by statistical methods.Results:The comparison of gestational age，birth weight，prematurerupture of membranes，intrauterine distress and pregnant mother’s age is nostatistically significant in the hypoglycemia group.Blood glucose level lessthan1.5mmol/L were more frequent in HBI group，blood sugar value werelower than in NHBI group，and duration of hypoglycemia were higher thanNHBI group.Long-term follow-up of HBI，part of head imaging werenormal with a reversible phenomenon，part of children have cerebral palsy， epilepsy，and so on. The comparison of head circumferrnce，gestational，multiple pregnancy，mother’s age，prengnancy iduced hypertendion（PIH）and nenonate respiratory distress syndrome（NRDS）was statisticallysignificant in infant of diabetes mother groups.Conclusion:1.The gestational age，birth weight，intrauterine distress，premature ruptureof membranes and motherhood age were the risk factors of neonatalhypoglycemia repeated episodes.2.Symptomatic hypoglycemia have some tips on hypoglycemic braininjury，and the occurrence of convulsions suggested the occurrence ofhypoglycemic brain injury，On the other hand，frequent seizures willaggravate the hypoglycemic brain injury. The gestational age，birth weight，duration of severe hypoglycemia，lowest blood sugar levels and seizureswere associated with HBI.3.Parts of hypoglycemic brain injury is mainly in bilateral occipital lobeposterior cerebral tissue.The characteristic is bilateral and symmetricaldistribution，Some children are widely involved the cortex lesions.4.The follow-up，the HBI were9cases，normal groeth and developmentwere5cases and cerebral palsy and（or）epilepsy were4cases.5.Multiple pregnancy，intrauterine distress，mother’s age and PIH wereassociated with gestational diabetes mellitus mother neonatalhypoglycemia.