Clinical Analysis Of Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation In The Treatment Of Non-hodgkin’s Lymphoma In56Cases

Objective Study of autologous peripheral blood hematopoietic stemcell transplantation (APBSCT) in the treatment of non-hodgkin’slymphoma (NHL) of clinical efficacy.Methods A total of56patients who underwent APBSCT fromFebruary2009to October2013in the hematopoietic stem celltransplantation center of the first affiliated hospital of chongqing medicaluniversity were enrolled in the study, including41cases of B-celllymphoma and15cases of T-cell lymphoma.Results Among56patients treated by APBSCT,55patientsobtained hematopoietic reconstitution, and other patient has no obtained.The median time of neutrophils recovery (﹥0.5×109/L)time was9.5(7-18)days and platelet recovery (﹥20×109/L)time was11.5(6-24) days.Twenty-four patients in fever when granulocyte lack of phase,5patientswith mild-to-moderate diarrhea,1patient with mild liver function damageand1patient appeared herpes zoster. All patients were followed up endedon April1st,2014, and the median follow-up time of20.25(3-60.5)months. Forty-five cases survived, and5cases alive with disease;10cases of recurrence;11cases dead and5cases died of recurrence. The recurrencerate was17.9%. Overall survival (OS), disease-free survival (DFS) were80.4%,71.4%respectively.Conclusions Autologous peripheral blood hematopoietic stem celltransplantation is an effective method for treatment of non-hodgkin’slymphoma. Hematopoietic reconstruction fast and fewer complications.