Meta-analysis Of The Efficacy On Yiqihuoxue Chinese Medicine Treatment Of Coronary Heart Disease

ObjectiveBy system evaluating the efficacy of Yiqihuoxue Chinese medicine treatment of coronary heart disease, like Qishenyiqi pills, Tongxinluo Capsule, Naoxintong Capsule, Tongguan Capsule, to provide the basis for its application.Methodsâ‘ Retrieval Str ategy:To carry out electronic retrieval from CBM database, CNKI database, Wanfang database and Pubmed database using subject words like Qishenyiqi pills, Tongxinluo Capsule, Naoxintong Capsule, Tongguan Capsule, angina pectoris, myocardial infarction. Retrieval years is from the listing date of the drug to June2013.â‘¡Literature Evaluation:Two researchers carried out literature screening indendently according to the inclusion and exclusion criteria. Different ideas hangdled by the third party, we acquired characteristic data from related literature studis, and evaluated the methodology and report quality of RCT in accord with inclusion criteria. Meta analysis was by Revman5.2software.ResultsThe total number of literatures searehed was3912,44literatures existed after exclude duplicate reports removal of experimental design study literature, and non-randomized study, All tests was evaluated according to Cochrane Risk Assessment Tool, no Double-blind trial,"Funnel Plot" shows asymmetry, which indicates publication bias. In significant efficiency of improving angina symptoms, Western medicine combined with Chinese medicine therapy is better than simple Western medicine treatment. Total effective, excellent and effective aspect of the ECG effects, western medicine combined with Chinese medicine therapy is better than simple western medicine treatment. In subgroup analyzes, Whether stable angina and unstable angina subgroup, western medicine combined with Chinese medicine therapy is better in angina pectoris. And the tests found no serious adverse reactions. The adverse reactions arising from Chinese medicines are minor, its safety is acceptable.ConclusionIn Western medicine combined with conventional treatment based on Chinese medicine Yiqihuoxue can further improve the clinical symptoms and ischemic electrocardiographic changes in coronary heart disease, but the program reported less random, and no literature mention blinding, the low quality of the included studies, so does not exclude the presence of selection bias and performance bias; still need more multi-center, large sample, randomized double-blind research reports measure to get a more powerful evidence.