The Correlation Research Of STM And Hs-CRP With Hypercoagulability In Children With Nephritic Syndrome

ObjectiveComparing thrombomodulin (sTM) and high sensitive C reactive protein (hs-CRP) levels in children with primary nephrotic syndrome (PNS) and normal control group, and explore the correlation between it and the hypercoagulable state and predict thrombosis indicators.MethodAll the selected patients and control group were venous blood samples, using double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) to detect plasma sTM levels, using immunoturbidimetric assay of plasma hs-CRP levels; at the same time, with the simultaneous detection of blood lipid and electrophoresis, coagulation index, etc. Application of statistical methods to compare the case group and the control group sTM and hs-CRP levels, and to analyse the correlation between sTM and hs-CRP in case group and blood lipid, blood coagulation index.Result1. The levels of plasma TM in children with PNS significantly increased compared with normal control group, there was statistically significant difference (t=12.545,P=0.000), The levels of plasma sTM significantly decreased after urine protein negative than before hormone treatment, the difference was statistically significant (t=6.298,P=0.000).2. The levels of plasma TM in children with PNS had positive correlation with24h urine protein (r=0.379, P=0.000); with LDL (r=0.203, P=0.024), APOB (r=0.184, P=0.041), lpa (r=0.177, P=0.050); and with APTT (r=0.295, P=0.001), TT (r=0.307, P=0.001), fg (r=0.224, P=0.024).3.The levels of plasma hs-CRP in children with PNS significantly increased compared with normal controls, there was statistically significant difference (t=3.487,P=0.001), the level of plasma hs-CRP significantly decreased after urine protein negative compared with before hormone treatment, there were statistically differences (t=5.473,P=0.000).4. It Is negatively related to hs-CRP and ALB in children with PNS (r=-0.194., P=0.030), and positively correlated with fg (r=0.257, P=0.009).5. Plasma sTM and hs-CRP levels in children with PNS were positively correlated relationship(r=0.395, P=0.004).Conclusion:1. There have glomerular vascular endothelial injury in NS, sTM may be used as one of the reference indicator of NS activity.2. sTM possibly through the double impact directly on the coagulation process as well as lipids, involved in the formation process of PNS hypercoagulable state. The levels of sTM may be a reference index with PNS in hypercoagulable state and prediction of thrombosis.3. The levels of plasma hs-CRP reflected the micro-inflammatory state in children with PNS, and involved in the formation of hypercoagulability in PNS by effecting blood coagulation process, hs-CRP should be used as indicators for monitoring the hypercoagulability of active PNS.4. Both of sTM and hs-CRP may through effects on coagulation process, involved in the formation of high coagulation state. But whether both work in the same way, still needs further study.