| Background and objectivesWith the new technology development of Magnetic Resonance Imaging,such asgradient-echo T2*weighted imaging (GRE-T2*WI) and susceptibility-weightedimaging (SWI),Cerebral microbleedings (CMBs) being clinicians and researchers’attention gradually. CMBs performance on the SWI sequence of2-10mm round orsimilar round signal reduce the area and surrounding without edema, whileexcluding lacunar cerebrovascular around, leptomeningeal hemosiderin depositionor calcification. histopathology has confirmed that CMBs mainly due to cerebralsmall artery lesions. Lacunar infarction, leukoaraiosis and cerebral microbleedshave a common basis for disease management.So,CMBs is an important sign ofsmall vessel disease.Previous studies have shown that patients with acute cerebralinfarction occurred CMBs with old age,hypertension,lacunar infarction,leukoaraiosis, cerebral amyloid angiopathy, apolipoprotein E (APOE) ε4alleleand other factors. These risk factors in patients with acute cerebral infarction is thatthey analysis the people of acute cerebral infarction as a whole.While differentTrial of Org10172in Acute Stroke Treatment (TOAST) classification of patientswith cerebral infarction risk factors for CMBs occur whether there are differences.there are no studies on this aspect. Small cerebral artery occlusion is a common types of TOAST classification, and has the basis of small vessel disease. this studywant to investigated the risk factors associated with the people with small arteryocclusion.To provide a theoretical basis for the secondary prevention of acuteinfarction.MethodsSource PopulationBased on the prospective consecutive database of neurology department of the firstaffiliated hospital of Zhengzhou University,retrospective analysis the first-time acutesmall-artery occlusion cerebral infarction patients from Jan2012to Oct2013, whounderwent the SWI.MethodsPatients who met the inclusonal criteria were enrolled and registered consecutively,the researchers recorded the baseline clinical characteristics in the standard CaseReport Form (CRF).(1) Written consent: All the patients or their relatives signed the writtenconsent and were informed of the benefits of parpicipating this trial, theycan withdrawl this study at any time of the study.(2) Record the baseline data: These include the basic information(demographics, contact information), past history (risk factors, history ofcerebrovascular disease, history of cardiovascular and other diseases, etc),personal history, TOAST classification, imaging studies (includingmagnetic resonance conventional sequences,SWI sequence) and laboratorytests (including blood lipids, blood clotting, blood homocysteine, etc.)andother information.(3) Theclinical data were input to and analyzed by SPSS17.0, count data usingchi-square test, measurement data using t test, Wilcoxon rank sum test data,CMBs risk factors assessed using multivariate Logistic regressionanalysis.The number of Cerebral microbleedings with leukoaraiosis, lacunarinfarction severity use spearman correlation analysis. p<0.05was regarded forstatistical significance. ResultsA total of109patients meeting the inclusion criteria were enrolled, male75cases(68.8%) and34females (31.2%), the mean age was64.0±12.4(30~91), SWI (+)47cases, SWI (-)62cases,51cases of patients with hypertension (46.8%),22cases ofdiabetic (20.2%),9patients with coronary heart disease (8.3%),22patients withsmoking history(20.2%), drinking history14cases (12.8%).Compared with SWI(+)and SWI(-),the results showed that age (p=0.037), hypertension (p=0.000),triglycerides (p=0.005), LDL (p=0.046), thrombin time (p=0.041), partialthromboplastin time (p=0.010), international normalized ratio INR (p=0.016) aredifference and statistically significant (p <0.10).Cerebral microbleedings grouping as the dependent variable, the univariateanalysis meaningful variable,such as age, hypertension, LDL, thrombin time, partialthromboplastin time, international normalized ratio, lacunar infarction, leukoaraiosis,triglycerides third-class classification as independent variables, Logistic multivariableregression analysis showed that hypertension[OR=6.368,95%CI2.279~17.799：p＜0.001],lacunar infarction[OR=3.876,95%CI1.180~13.912:p=0.038],leukoaraiosis[OR=16.797,95%CI1.433~196.960:p=0.025],triglyceride≥1.52mmol/L[OR=0.027，95%CI0.074~0.983：p=0.047]were related to CMBs. spearman correlation analysis suggested that severityof lacunar infarction and leukoaraiosis were also positive related to CMBs(r=0.520,r=0.553; both p <0.001).ConclusionsHypertension,lacunar infarction,leukoaraiosis,triglyceride≥1.52mmol/L are related tothe first-time acute small-artery occlusion cerebral infarction patients who has CMBs.hypertension,lacunarinfarction,leukoaraiosis maybe the risk factors.triglyceride≥1.52mmol/L maybe a protective factor. |
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