Expression Of P65Protein In Gastric Carcinoma And Correlation Between The Clinicopathology

Objective. This study is aimed to investigate the roles of P65expression in tumorigenesis and the correlation with clinicopathological features in gastric cancer tissue microarrays.Methods. The expression of P65protein was evaluated by ABC method of immunohistochemical staining in121gastric cancer and39normal gastric tissue samples.Results. The positive rate of P65protein was69.5%and20.5%in gastric cancers and normal gastric tissues, respectively (P<0.01). The positive expression of p65protein in90cases of male of gastric carcinoma and31cases of female gastric carcinoma were74.4%and64.5%, no significant difference between the two groups (P>0.05). The positive expression in42cases of60years old and79cases over60years old in gastric carcinoma were64.3%and75.9%(P>0.05). The positive expression was in diameter less than5cm in68cases of gastric carcinoma and diameter greater than5cm in53cases of gastric carcinoma were66.2%and79.2%(P>0.05). The positive expression of â… -â…¡ in39cases of gastric cancer tissues and83cases of grade â…¢-â…£ in gastric carcinoma were43.6%and85.4%(P<0.01). In49cases of early stage gastric cancer and72cases advanced gastric cancers, the positive expression in14cases invasive into the muscular layer and58cases invasive into the mucosa and submucosa in gastric carcinoma, p65expression rate was respectively57.1%,78.6%and82.6%, significant compared with the positive rate of p65protein expression in early gastric cancer and advanced gastric cancer tissue (P<0.01). P65expression in gastric cancer was also correlated with lymphatic metastasis (P<0.01) and distance metastasis (P<0.01).Conclusion. P65plays an important role in the progression of gastric cancer. High level of P65expression in gastric cancer was correlated with clinical stage, invasiveness, lymphatic metastasis and distant metastasis. P65expression is not correlated with the sex, age and tumor size. P65expression predicts the poor prognosis of patients with gastric cancer and it might be potentially used as an independent effective biomarker for prognostic evaluation of gastric cancers.