Study Of The Correlation Between Knee Osteoarthritis And Post-menopausal Osteoporosis

Part ICorrelation of bone metabolic index with osteoarthritis andpostmenopausal osteoporosisObjective: To study the bone density and bone metabolic index of kneeosteoarthritis (KOA) and postmenopausal osteoporosis (PMO), and to discuss thecharacteristics of bone density and bone metabolic index in KOAand PMO.Methods: A total of248postmenopausal women were detected for bone mineraldensity and knee X-ray. Finally180patients were included in this study and weredivided into three groups: KOA group, PMO group, and control group. The levels ofbone turnover markers (bone alkaline phosphatase, bone gla protein, collagen type Icross-linked C-telopeptide, and tartrate-resistant acid phosphatase5b) in serum fromthe participants were measured. The correlation between bone turnover markers andthe disease progression was analyzed by Logistic regression analysis.Results: The bone mineral density in the KOA group was higher than the controlgroup but collagen type I cross-linked C-telopeptide was lower. The levels of bone glaprotein, collagen type I cross-linked C-telopeptide, and tartrate-resistant acidphosphatase5b in serum from PMO group were higher than the control group. Thedecrease of collagen type I cross-linked C-telopeptide was associated with theincidence of KOA, and the increases of bone gla protein, collagen type I cross-linkedC-telopeptide, and tartrate-resistant acid phosphatase5b were associated with theincidence of PMO.Conclusion: The lower bone absorption can be seen in postmenopausal womenwith KOA. PMO patients showed a higher bone turnover rate. The difference of bonemetabolism between patients with KOA and PMO led to negative relationship of bonemineral density. The serum levels of bone gla protein, collagen type I cross-linkedC-telopeptide, and tartrate-resistant acid phosphatase5b can assist clinical diagnoseand therapeutic effect detection of both KOA and PMO. Part II Clinical study on change of bone mass and bone turnover inpostmenopausal osteoporosis patients with osteoarthritisObjective: To study the effect of knee osteoarthritis (KOA) on postmenopausalosteoporosis(PMO) by measuring the bone mineral density(BMD) of lumbar and hipcouple with bone metabolism marks（BTM） in groups of PMO patients withdiffrernt grades of KOA.Methods: the sample of328were diagnosed as PMO, were assessed forradiographic features of KOA.and the BTM include BAP、 BGP、CTX-1、TRACP5b、25-vitD3、PTH serum levels were measured. the factors were comparedamong the patients with different classes of KOA.Results: BMD、BAP、CTX-1、TRACP5b were different among the PMO groupand the PMO with different classes of KOA group.(P＜0.05),The PMO with IVKOA group was shown a significant higher BMD and lower serum levels of BAP、CTX-1、TEACP5b compared with the PMO without KOA group, The PMO with IKOA group was shown a significant higher serum level of CTX-1compared with thePMO without KOAgroup.Conclusion: The decrease of BMD contributes to the incidence of KOA. KOAcould protect PMO patients from the decrease of BMD mediated by a lower rate ofbone resorption. The serum level of CTX-1as a sensitive index provides an usefulmethod to clinical diagnose and therapeutic effect detection of both KOA and PMO.