Expression And Clinical Significance Of PUMA In Actinic Keratosis And Cutaneous Squamous Cell Carcinoma

Objective Measure the expressions of PUMA in actinic keratosis and cutaneoussquamous cell carcinoma．Methods Expression of PUMA was detected in20cases of normal skin28cases ofactinic keratosis and32cases of cutaneous squamous cell carcinoma byimmunohistochemical PV two-step method，and analyzed their expressions and theircorrelation with clinical pathological parameters of colorectal carcinoma．Results The expression of PUMA in normal skin tissues was higher than that inactinic keratosis and squamous cell carcinoma (P<0.05)，the positive rate of PUMAin norma1skin tissues，actinic keratosis and cutaneous squamous cell carcinomawere75.00％,46.43%％and34.38％.The expression of PUMA in cutaneoussquamous cell carcinoma was not correlate with tumor of differentiation andnationality (P>O.05).Conclusions (1) The expression of PUMA positive are mainly in the cytoplasm.Compared with normal skin tissues, expressed in AK、CSCC organization wasgradually reduced.(2) The expression of PUMA in normal skin group is higher thanAK and CSCC, it have statistically significant in the3groups.(3)The expression ofPUMA in cutaneous squamous cell carcinoma was not correlate with tumor ofdifferentiation(well and poor) and nationality(han and zang)(4)The down regulationof PUMA may take part in the progression and proliferation of actinic keratosis andcutaneous squamous cellcarcinoma.