Correlation Research Of IL-1β、IL-6and TNF-α Effects On The Rheumatoid Arthritis Patients Supervene With Diabetes Mellitus

Objective:To explored the correlation of cytokines such as IL-1β、IL-6andTNF-α in the Rheumatoid althritis(RA) supervene with diabetes mellitus.Methods:Selected30RA patients supervene with diabetes mellitus,40merelyRA patients without other diseases,30Type2Diabetes(T2DM)and30health controlgroup.Each of them adopted ELISA to test serum level of IL-1β、IL-6and TNF-α.Results:The serum level of IL-1β、IL-6and TNF-α in the RA supervene withdiabetes mellitus group are significantly higer than merely RA group (p<0.05,p<0.001, p<0.001.respectively), merely RA group serum IL-1β, IL-6, TNF-α levelsare significantly higer than the T2DM group (p<0.001, p<0.05, p <0.05.respectively).RA serum IL-1β, IL-6, TNF-α levels were also significantly higher than the controlgroup (p<0.05, p<0.001, p<0.001.respectively), the difference was statisticallysignificant, and T2DM group serum IL-1β the level of IL-6and TNF-α is also higherthan the healthy control group（p<0.05、p<0.001、p<0.05.respectively）, the differencewas statistically significant. HOMA-IR values and serum IL-1β, IL-6, TNF-α werepositively correlated (r=0.65, r=0.60, r=0.58. respectively.p<0.01); RA patients withserum IL-1β, IL-6, TNF-α levels and DAS28disease activity score was positivelycorrelated (r=0.53, r=0.63, r=0.59. respectively.p<0.01), HOMA-IR values andDAS28disease activity score was positively correlated (r=0.55, p<0.01).Conclussion:1) The serum level of IL-1β, IL-6and TNF-α in RA patients weresignificantly elevated, RA complicated by diabetes mellitus is closely related to serumcytokine elevated;2) RA disease activity higher the more easily cause insulinresistance, resulted in glucose metabolism, the more obviously. In vivo studiessuggest that the elimination of inflammatory cytokines in patients with RA in additionto controlling activities but also to improve its concurrent glucose.