A Study On The Relationship Between Organochlorine And Female Breast Cancer

Objective To describe the serum organochlorines residues and explore the relationshipbetween organochlorines exposure and the female breast cancer. Therefor, We can offermethods and evidences to the control and Prevention of breast cancer and illuminate theetiologieal factor and mechanism to a further and deeper step.Methods A1:1matched case-control study was designed.The cases are107primaryfemale breast cancer cases which are newly-happened and Patho-definited, the controls are107patients without breast disease and107patients with benign breast disease who arematched with investigate time, residence and age.All cases and controlls were collected fromMay,2010to May,2011in Ningxia medical university general hospital. All the subjects havebeen informed with the specific purpose of our research and all of them have agreed.Consequently, The datas in general state of health，reproductive and endocrine factors, eatinghabit,life style,patienthistory and history of family malignancy were investigated and bloodwere collected. The contents of organochlorines such as PCBs, HCH and DDT were detectedand analyzed by gas chromatograpy electron capture detector. A database SPSS11.5wasestablished, the organochlorine exposure level in serum was compared with rank sum test,theadjusted odds rations (OR) of organochlorines residues to breast cancer were evaluated byconditional logistic regression model.Results1.The serum organochlorine residues of cases and controls.15organochlorineresidues could be detected in serum of cases and controls. The detecting rates ofβ-HCH,δ-HCH,p,p’-DDE,PCB28and PCB52were higher than90%, there were no significant differences of detection rate between cases and controls(P＞0.05). The mediancontents of PCBs, DDT and HCH among controls are2.3422ng/ml,1.2879ng/ml and7.6887ng/ml.2. The relationship between the organochlorine residues and breast cancer. Thedifferenceses of15-kinds organochlorine pollutants between case and control were comparedby rank sum test. The content of β-HCH, p,p’-DDE, PCB52and total DDT among cases arehigher than that in controls(P＜0.05), The content of β-HCH, p,p’-DDE, PCB52, total DDTand total PCBs among cases are higher than that in patients with benign breast disease(P＜0.05). The serum organochlorines residues are divided into three levels by serumorganochlorine residues quartile (P25,P75) of normal control, in order to avoidmulticollinearity between organochlorines, organochlorine residues were analyzed withinfluencing factors of breast cancer respectively. After adjusting confounding factors, β-HCH,p,p’-DDE and PCB52were positively related to the risk of breast cancer (OR＞2,P＜0.05).Conclusions The organochlorine pollutants (HCH, DDT, PCBs) can be detected in breastcancer cases, patients with benign breast disease and patients without breast disease. Thedetecting rates of β-HCH, δ-HCH, p,p’-DDE, PCB28and PCB52were higher than90%.2.Organochlorine exposure may be associated with the incidence of breast cancer, the higher thelevel of exposure, the greater the risk of breast cancer.β-HCH, p,p’-DDE and PCB52werepositively related to the risk of breast cancer.