| IntroductionCachexia is a common complication in patients with advanced cancer, which is poses a serious impact to the patients’survival time and quality of life. It causes a huge concern to the medical community, patients and their families. Modern medicine considers that cachexia occurrence and biochemical metabolism, energy metabolism, is closely related to the role of cytokines. Cancer cachexia has a common symptom of clinical weight loss in the short term wife, anorexia, malnutrition, fatigue, exhaustion, fat and muscle groups of consumption and organ dysfunction. Progesterone is the first choice for the advanced cancer cachexia, can increase appetite and weight, but because of thromboembolic reactions, cardiovascular effects, urogenital system response and side effects such as endocrine system response many patients thus reducing the remaining survival time quality of life or reject the medicine.There is no the disease name "cachexia " is not exist in the areas of medicine, but cachexia symptoms and the documents in ancient medical books of "Consumption" is extremely similar. Learning from the symptoms it can also be attributed to cachexia "Consumption" category Zhang ZhongJing documented. About Treatment on dialectical therapy clinical medicine has many treatments, Professor mentor Feng Li based on years of clinical experience in cancer creating the TX to cure cancer cachexia patients caused by cold and heat has a clinical efficacy.ObjectiveThrough comparative analysis on patients’weight, Karnofsky score, appetite status, TCM clinical symptom score with the day before treatment, the first day and fifteenth day after treatment, to evaluate the clinical efficacy of TX in the treatment of advanced cancer cachexia.Find a more effective treatment methods to improve the quality of life and prolong survival time for the treatment of patients with advanced cancer cachexia.MethodsAccording to the methods a randomized controlled clinical trial, the group will meet the entry criteria of63patients were randomly divided into treatment group (32cases) and control group (31cases) groups. Treatment group adjust stomach and awake the spleen prescription square add water200ml and fried, bid, each100ml, take after breakfast, after dinner30min with warm water. The control group received megestrol acetate tablet160mg/times, after the bid, breakfast, after dinner30min with100ml warm water. Two cases each take one week for a treatment cycle. Therefore, two cycles of treatment. Observe Karnofsky score changes in the day before treatment, the first day and fifteenth day after treatment, changes in appetite and condition, changes in weight status, clinical symptoms, improve quality of life and so on.Results the first day after treatment,the day before treatment,the fifteenth day after treatment1Baseline analysisTwo groups of patients at baseline gender, age at baseline, baseline and treatment of disease before weight, KPS score, appetite, the total score from baseline clinical symptoms, the statistical results showed no significant difference between the two groups (P>0.05).2Evaluation2.1The fifteenth day after the end of the first day treatment compared with before treatment after treatmentThe fifteenth day after the end of the first day after the end of treatment compared with treatment before treatment, there is a certain treatment group and the control group.2.2the first day after treatmen compared with the day before treatment-Two groups of patients in improving body weight, KPS score, loss situation and TCM symptom score in weight loss, shortness of breath, fatigue aspect, no significant difference (P>0.05). In terms of total symptom score improvement of Chinese medicine and Chinese medicine symptom scores in anorexia, there was significant difference (P<0.05), abdominal distension aspects.2.3The fifteenth day after treatment compared with the day before treatmentTwo groups of patients in terms of improving body weight and TCM symptom score in weight loss, shortness of breath, no significant difference (P>0.05) weak areas. Improving KPS, appetite, the total symptom score and TCM TCM symptom scores in anorexia, there was significant difference (P<0.05), abdominal distension aspects.Conclusions(1) TX qualitative has some effect to increase in advanced cancer patients with cachexia weight, KPS score, appetite, the TCM symptom score.(2) In terms of short-term efficacy and long-term efficacy, TX with Megestrol Acetate has a considerable effect in improving the quality of patient body weight with advanced cancer cachexia.(3) TX with Megestrol Acetate has no significant difference in improving the quality of patients with advanced cancer cachexia KPS, in terms of short-term efficacy of appetite circumstances.(4) From the point of view of long-term efficacy, TX in improving cancer cachexia in patients with advanced disease KPS, appetite situation better than Megestrol Acetate.(5) Improvement of clinical symptoms in patients with total integration, whether it is short-term or long-term efficacy of efficacy, TX are superior to Megestrol Acetate.(6) Either in the short or long-term efficacy of efficacy, TX integral in terms of improving patient clinical symptoms of anorexia, abdominal distension symptom improvements were better than Megestrol Acetate. |
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