Yiqiyangyin Prescription United Medroxyprogesterone Acetate On The Treatment Of Lung Cancer Cachexia Belong To Deficiency Of Qi And Yin In Clinical Research

Objective:To observe the treatment effect of Yiqiyangyin Prescription united Medroxyprogesterone acetate in the lung cancer cachexia which belong to Deficiency of Qi and Yin. Through the assessments of patients in the aspects such as quality of life, clinical symptoms, appetite, body weight and serum albumin, prealbumin levels, obtain more about the treatment value in clinic, and exploit more wider future in TCM remedy to cancer cachexia.Methods:A randomized controlled method,30patients with lung cancer cachexia were randomly divided into2groups, the treatment group (combined Yiqiyangyin Prescription with Medroxyprogesterone acetate)15cases, the control group (treated with Medroxyprogesterone acetate)15cases. After one-month treatments two groups were observed before and late in patients with quality of life, clinical symptoms, appetite, body weight and serum albumin, prealbumin levels.Results:(1) Comparison of KPS score:After treatment, see the KPS scores increase in the control group and also obviously improved KPS scores in the treatment group which had more significantly diffrernces than the former (P﹤0.05).(2) Comparison of TCM clinical symptoms:The treatment group clinical symptoms improved in4cases,26.7%, stable in9patients,60%, invalid in2cases,13.3%. In the control group, clinical symptoms improved significantly after treatment in0case,0%, stable in4,26.7%,11patients ineffective,73.3%. There were significant differences between two groups (P<0.05).(3) Comparison of appetite:The treatment group significantly increased appetite in10cases,66.7%, stable in4cases,26.6%, invalid in1,6.7%. While in the control group significantly increased cases after treatment accounting for1,6.7%, stable in7,46.6%, useless in7,46.7%. Two groups had statistically significant differences (P﹤0.01).(4) Comparison of body weight:After treatment patients in the weight markedly increased in9cases,60%, stable in5cases,33.3%and1case ineffective,6.7%.5cases were markedly effective in the control group,33.3%, stable in8cases,53.3%,2cases ineffective,13.3%. Differences between the two groups after treatment showed no significant effect (P>0.05).(5) Comparison of serum albumin:see the albumin of the treatment group improve significantly while slightly in the control group after treatment, the differences between two groups after treatment were statistically significant (P<0.05).(6) Comparison of serum prealbumin:the level of prealbumin in the treatment group significantly improved after treatment, in the control group pre-albumin also increased, but the differences between the two groups after treatment were statistically significant (P<0.05).(7) Compared security of two groups:After treatment,10patients with no adverse reactions, accounting for66.6%,4cases (26.7%) for grade2, only1case (6.7%) for grade3adverse reactions.4patients in the control group without adverse reactions, accounting for26.7%,9patients (60%) a slight reaction,2patients (13.3%), grade3adverse reactions after treatment. There were significant differences between the two groups (P﹤0.05).Conclusion:Yiqiyangyin Prescription united Medroxyprogesterone acetate simply increase the body weight of patients as Medroxyprogesterone acetate alone, However, the former has more advantages than the latter in alleviating TCM clinical symptoms, increasing appetite, boosting up the quality of life and other aspects such as the increase of the serum albumin level or serum prealbumin. Accordingly higher clinical value can be seen in Traditional Chinese medicine treatment.