Diabetic Lower Limb Arteriosclerosis Obliterans Of Syndromes And Complications, Study The Relationship Between Complications

Purpose：Investigate the distribution law of different TCM syndromes in thepatients with diabetic lower limb arteriosclerosis obliterans (DLASO), andanalyze the relationship between DLASO and the Complications orcomorbidities of DM.Material and method：Collect the hospitalized patients with DLASO inDepartment of Endocrinology, Affiliated hospital of Liaoning University ofTraditional Chinese Medicine in recent three years(2009/09~2012/09).Syndromes of DLASO is divided into the following four types, deficiency ofboth Qi and Yin with blood stasis group, deficiency of both Yin and Yang withblood stasis group, humid and heat trapped spleen with blood stasis group,deficiency of Yin and redundancy of Heat with blood stasis, according to《Guidelines of clinical research of Traditional Chinese Medicine (Trial)》，《Diagnostics of Traditional Chinese Medicine》and Clinical PracticeGuidelines formulate by Department of Endocrinology of our hospital. Recordeach patient’s sex, age, course of DM, BMI, HbA1c, blood lipid, Complicationsand comorbidities of DM. The data were entered into computer and analyzedthrough the statistical software SPSS15.0. Measurement data are represented bymean±standard deviation(x±s), enumeration data are represented byconstituent ratio, frequency table and Percentage. Measurement data are testedby One-way ANOVA for normality and non-parametric tests when doesn’t meet normality. Enumeration data are tested by Chi-square Tests.Results：1. In total454patients, the constituent ratio of four TCM syndromes are sortedfrom high to low as deficiency of both Qi and Yin with blood stasis group＞humid and heat trapped spleen with blood stasis group＞deficiency of bothYin and Yang with blood stasis group＞deficiency of Yin and redundancy ofHeat with blood stasis. Deficiency of both Qi and Yin with blood stasis groupis the most common syndrome with381patients(83.92%), and has statisticalsignificance compared with other groups(P＜0.05).2. The male female ratio of these patients with DLASO is1.29:1, there hasstatistical significance(P＜0.01). In the aspect of age and course of DM, therehas no statistical significance between groups(P＞0.05); BMI of deficiencyof both Yin and Yang with blood stasis group(26.43±4.11kg/m~2) is higherthan deficiency of both Qi and Yin with blood stasis group’s(24.91±3.12kg/m~2)(P＜0.05).3. The differences of HbA1c, TG, TC, LDL have no statistical significancebetween groups(P＞0.05). Deficiency of both Qi and Yin with blood stasisgroup’s HDL(1.20±0.34mmol/L) is higher than humid and heat trappedspleen with blood stasis group’s(1.10±0.29mmol/L)(P＜0.05).4. Humid and heat trapped spleen with blood stasis group has the most patientscomplicated hypertension(38,79.17%), and there has statistical significancecompared with deficiency of both Qi and Yin with blood stasis group(245, 64.30%)(P＜0.05); deficiency of both Yin and Yang with blood stasis grouphas the most patients complicated diabetic nephropathy(11,45.83%), andthere has statistical significance compared with humid and heat trappedspleen with blood stasis group(9,18.75%)(P＜0.05).Conclusion：1. Deficiency of both Qi and Yin with blood stasis is the most commonsyndrome in DLASO.2. The risk of developing DLASO for male is higher than female.3. Patients of Humid and heat trapped spleen with blood stasis group are easiercombined with hypertension than patients of deficiency of both Qi and Yinwith blood stasis group; patients of deficiency of both Yin and Yang withblood stasis group are easier combined with diabetic nephropathy thanpatients of humid and heat trapped spleen with blood stasis group.