Clinical Significance And The Relationship In TCM Of Eosinophile Granulocyte In Chronic Sinusitis Patients

Chronic sinusitis is named "persistent turbid nasal discharge" of TCM. It ischaracterized by mucopurulent discharge、nasal obstruction、head pain anddysosphresis. The inflammation in nasal sinuses mucosa will last above 12 weeks. It’sone of the nasal chronic disease in clinic and brings severity contribution in physicaland mental health and economy. It’s main cause include infect、allergic effect and theblockage of ostiomeatal complex, but the pathogenesy is till not identified. Recentlythe report about clinic significance of eosinophile granulocyte(Eos) in chronicsinusitis increases gradually. Eos is not the result of allergy, but also concerned withimmunological regulation. Chronic sinusitis can be classified into cholmeridian heataccumulation、splenogastric hygropyrexia、asthenia of pulmonosplenic qi of TCMand 1、2、3 type of western medicine in this text. We approach the etiological factor、pathogenesis、the effect of Eos、treatment and research the clinical significance aswell as the relationship in TCM of Eos.Objective: We approach the relationship between different type of syndromeand inflammatory infiltration in nasal mucosa of Eos、the influence of allergy inorder to raise the clinical observation value, to instruct better syndrome differentiationin TCM and the perioperative medication. We make sure to elevate the cure rate anddecrease the recidivism.Methods: 27 cases have been carefully chosen as study subjects according to thewestern medicine and the TCM diagnostic criterion of chronic sinusitis, aged 18 to69 years. Chronic sinusitis can be classified into 1、2、3 type of western medicine andcholmeridian heat accumulation、splenogastric hygropyrexia、asthenia ofpulmonosplenic qi of TCM. Everyone’s symptom scores are obtained, at the sametime, Eos and IgE in blood serum with the number of Eos、IgE、the total number ofinflammation cells and in the tissue are counted and compared at 400×magnification.20 deviation of nasal septum patients aged 16 to 52 years are served as controls fordiscussing the infiltration of Eos in patients with chronic sinusitis.Results: Decreased level of Eos in blood serum are detected when comparedwith control subjects(P＜0.01), and displayed negative correlation. The level of Eos inthe nasal mucosa increased when compared with control subjects(P＜0.01), and correlated with IgE in blood serum (r=0.405, P＜0.05)、the total number ofinflammation cells in the nasal mucosa (r=0.874, P＜0.01), IgE in the nasal mucosa(r=0.009, P＜0.01). Symptom scores and IgE in the nasal mucosa increased in the1、2、3 type of western medicine by turns, as well as in the grouping of TCM. Thecontents of Eos are not different in statistics between the allergic group andno-allergic group.Conclusion: According to this study, the Eos and total number of inflammationcells in the nasal mucosa are higher in chronic sinusitis patients than in controls, butthe Eos in blood serum is opposite. There is Eos infiltration in the nasal mucosa inmost chronic sinusitis patients concerned with the inflammation degree, and allergy isone cause of the Eos infiltration. The level of IgE in tissue is higher in the astheniasyndrome, so allergy should be considered when determination of treatment based inpathogenesis obtained through differentiation of symptoms and signs is applied.