Studying Of Relationship Between Risk Stratifications, Arteriosclerosis Of Essential Hypertension And TCM Syndromes

Objective: Study on the distribution regularity of TCM syndrome patterns of essentialhypertension (EH) and the correlation among the grade and course of disease, age, riskstratifications of EH, arteriosclerosis index of brachial ankle pulse wave velocity(baPWV)and syndrome patterns, to provide a sufficient evident of differentiation of syndromes incombination of Chinese traditional and western medicine, to advance clinic level fordifferentiation of symptoms and treatment.Methods: Totally 183 patients with essential hypertension are divided into four groupaccording to the Standardization of Syndrome Of the Guide Book of New TCMPharmaceutic Clinical Research (2002 edition), count the frequency of four syndromespatterns and the distribution among the grade, course of disease, age and risk factor of EH,arteriosclerosis index of baPWV and syndrome patterns, make them comparison andanalysis. About indexes were compaired with 30 cases of normal people.Results: 1. Arrange four TCM syndrome patterns of EH according to their constitute ratioin order: excessive phlegm-dampness syndrome＞yin deficiency and yang hyperactivitysyndrome＞yin-yang deficiency syndrome＞liver-fire hyperactivity syndrome. 2. Thesyndrome of liver-fire hyperactivity are known as the majority of grade 1 and grade 2 ofEH and the other three syndromes are known as the majority of grade 2 and grade 3 of EH.There is no statistical significances. 3. The four syndroms’ blood pressure is differentsignificantly from the normal. The syndromes both yin-yang deficiency and liver-firehyperactivity are higher in the systolic blood pressure than the other two syndromes. Thesyndrome of liver-fire hyperactivity is the highest in the diastolic blood pressure. But thereis no statistical significances. 4. The high risk group and the very high risk group hold abigger position in the two syndromes of excessive phlegm-dampness and yin-yang deficiency. The two syndromes are different significantly from the other two syndromesin the risk stratifications. 5. BaPWV of all the TCM syndromes of EH is higher than thenormal. The syndromes of excessive phlegm-dampness and yin-yang deficiency aresignificantly different from the other two syndromes. 6. The two syndromes ofexcessive phlegm-dampness and yin-yang deficiency are different significantly from theother two syndromes in the age and duration of disease.Conclusion: 1. The distribution and change of TCM syndromes of EH is regular. Theessence of EH is asthenia in the root and sthenia in the branch that kidney is the root andliver is the pathological changes. There is a ragula that TCM syndromes of EH areliver-fire hyperactivity and yin deficiency and yang hyperactivity in initial stages and theother two in anaphase along with the gradual increasing of age and duration ofdisease. 2. There are significant different in the risk stratifications between the syndromes ofexcessive phlegm-dampness and yin-yang deficiency and the other two syndromes, whichindicated that the former are more liable to get cardiovascular diseases. 3. The increase ofbaPWV as the cardiovascular danger factor can be applied as the subjective index for thesyndromes of excessive phlegm-dampness and yin-yang deficiency. 4. Treate the case ofessential hypertension we must not only control BP, but control cardiovascular dangerfactors and prevent target organ damage(TOD). Treat the case of excessivephlegm-dampness and yin-yang deficiency, we must control the lever of BP, cultivatekidney and liver and expet phlegm to decrease arteriosclerosis index of baPWV.