The Clinical Application Value Of New Methods On Cervical Cancer Screening

Objective:To evaluate the two new methods, stability test kit of the uterine epithelial cells (FH test) and cervical cancer fast self-check kit (FST-SH), clinical significance in screening cervical precancerous lesions and cervical cancer.Objects and methods:A total of492female who visited Qilu Hospital of Shandong University gynecological clinic for cervical cancer screening from October2012to March2014. The participants’average age was39years old ranging from15to75years old. All the participants should take gynecological examination, the TCT, HC-II and pathologic biopsy,134participants were diagnosed with cervical precancerous lesions (including CINI, CINII, CINIII);68participants were diagnosed with cervical cancer;290participants were diagnosed with other gynecological diseases with normal cervical. Using the FH test and FST-SH two methods respectively to test all the participants above, and then judge the results according to the chromogenic reaction. Record the patients’age, health status, test results of the TCT, HC-II, histopathological examination findings, FH test and FST-SH results. Checking all the results and importing to the SPSS software for statistical analysis, verify the clinical application value of the two new technologies for cervical cancer screening.Results:(1)In the study the Se of FH test, FST-SH、TCT, HC-II were90.6%,87.1%,90.1%,97.0%; Sp were80.7%,81.7%,94.1%,88.3%; E value were84.7%,83.9%,92.5%,91.9%; with pathological examination deemed as the gold standard, the K value of three tests were0.694,0.675,0.833,0.835(P<0.05), have obvious consistency with the pathological results.(2)In the FH test the positive rate of cervical precancerous lesion group, cervical cancer group and normal cervical group were87.3%,97.1%,19.3%respectively. In the FST-SH the positive rate of cervical precancerous lesion group, cervical cancer group and normal cervical group were82.8%,95.0%,18.2%respectively. In the TCT test the positive rate of cervical precancerous lesion group, cervical cancer and normal cervical group were88.8%,92.6%,5.9%respectively; In the HC-II the positive rate of cervical precancerous lesion group, cervical cancer group and normal cervical group were96.5%,100%,11.7%respectively. To compare those four screening methods of the data differences in cervical precancerous lesion group and cervical cancer group, the differences between FH test, FST-SH and TCT were no statistical significance (P>0.05); but it had statistical significance HC-II and three other methods (P<0.05).(3)In the five parallel tests, FH test combined with TCT, FH test combined with HC-II, FST-SH test combined with TCT, FST-SH test combined with HC-II, HC-II test combined with TCT, the Se were higher than the other Single detection methods, but the Sp were reduced.Conclusion:(1)The stability test kit of the uterine epithelial cells (FH test) and cervical cancer fast self-check kit (FST-SH) as new methods for cervical cancer screening are simple, cheap, safe and effective, and they also don’t need professional medical personnel and equipment. Although the Se and Sp in the two new methods were lower than the TCT and HC-II, but they all80%above high, still have a good clinical application value.(2)FH test and FST-SH combine with TCT and HC-II respectively for cervical cancer screening have a higher Se with lower rate of missed diagnosis, the accuracy is improved obviously.