| Objective Asymptomatic inflammatory (NIH-IV) Prostatitis and therelationship between the serum total PSA (tPSA) level.Methods Data were collected from878men who participated in thepopulation-based Fangchenggang Area Male Health and Examination Survey(FAMHES), which was carried out in Guangxi, China, from September2009toDecember2009. A face-to-face interview was conducted by trained physiciansfrom the First Affiliated Hospital of Guangxi Medical University andFangchenggang First People’s Hospital Medical Centre. Each participant wasasked to complete a standardized questionnaire containing detailed informationon sociodemographic and life-style factors as well as the Chronic ProstatitisSymptom Index(NIH-CPSI) questionnaire at the time of recruitment. Aface-to-face interview was conducted by trained physicians to get the basicinformation of each participant. Anthropometric measurements were performedby trained personnel using a standardized protocol. Overnight fasting venousblood specimens were drawn. Triglycerides (TG), high-density lipoprotein cholesterol (HDL-c) and serum glucose were measured enzymatically on anautomatic analyzer (Dade Behring, USA). Serum PSA levels were measured byelectrochemiluminescence immunoassay on COBAS6000system E601(Elecsysmodule) immunoassay analyzers(Roche Diagnostics, GmbH, Mannheim,Germany) with the same batch of reagents. Participants were encouraged toprovide EPS specimens after prostatic massage for analysis, Polypropylenecontainers containing EPS were brought to clinic laboratory immediately. Wetmounts were made and examined promptly with a high power microscope(400×). According to the NIH-type IV and presence of inflammtion in EPS, thesample was divided into NIH-type IV prostatitis group and healthy group.Statistical analysis was conducted using t test, chi-square test, logisticregression．Results Serum tPSA levels in the healthy control group and the NIH-type IV prostatitis group were0.91±0.79and1.27±1.52(ng/ml), the differencewas statistically significant (P <0.001). In the two groups, the level of education,exercise, high blood pressure were significantly different (P=0.002, P=0.007,P=0.011, respectively). However, there is no significant difference betweenthe two groups in BMI, total cholesterol, high density lipoprotein, LDL, fastingblood glucose. Similarly, there is no statistical difference between the twogroups in the proportion of drinkers, dyslipidemia, obesity, diabetes, smokingconstituent. The sample was divided into four groups according to the quartilefo the serum tPSA levels were(Q1, Q2, Q3, Q4,respectively). Comparison ofNIH-type IV prostatitis degree of risk of illness, the results showed that in theNIH-type IV prostatitis (wbc≥3+) group comparison healthy control group,with an odds ratio of serum tPSA level increments (odds ratios, OR) is also increasing, OR1.078, respectively,3.589,4.406. In the group with serum tPSAQ4increased inflammation OR also increments, OR are1.573,3.147,4.406.Binary logistic regression model, further adding age, education level,dyslipidemia, diabetes, hypertension, BMI, smoking, alcohol consumption,exercise, diastolic and systolic blood pressure as an adjustment variable. Theresults show that higher serum tPSA levels, the higher the risk of NIH-type IVprostatitis. After adding age (Model1), with Q1group as the reference group,NIH-type IV prostatitis group, Q2, Q3, Q4group OR was1.45(95%CI0.92-2.34),1.60(95%CI1.00-2.54)*,2.15(95%CI1.37-3.36)*,*representsP value of <0.05, OR value trend test, P <0.05. Continue adding educationallevel, dyslipidemia, diabetes, hypertension, BMI, smoking, alcohol consumption,exercise, diastolic and systolic blood pressure as an adjustment variable (model2), the results showed Q2, Q3, Q4group OR was1.46(95%CI0.91-2.35),1.62(95%CI1.01-2.60)*,2.11(95%CI1.33-3.33)*,*represents P value of <0.05,OR value trend test, P <0.01. According to WBC count, NIH-type IVprostatitis into wbc+1, wbc+2, wbc≥3three subgroups, the NIH-type IVprostatitis (wbc≥3+) in, Q1group as a reference group, the model1showedQ2, Q3, Q4group OR values were1.10(95%CI0.27-4.49),3.59(95%CI1.15-11.25)*,4.13(95%CI1.32-12.87)*,*represents P value <0.05, ORvalue trend test, P <0.001. Model2showed Q2, Q3, Q4group OR values were1.08(95%CI0.26-4.43),3.88(95%CI1.22-12.32)*,4.00(95%CI1.27-12.63)*,*represents P value <0.05, OR values for trend test, P <0.01.Conclusions High levels of serum tPSA level is a potential RiskFactors for asymptomatic inflammatory (NIH category IV) Prostatitis; NIH-type IV prostatitis patients with white blood cells of EPS levels were positively correlated with serum tPSA levels. |
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