Serum High-sensitivity C-reactive Protein And Skeletal Muscle Intramyocellular Lipid Changes And Influence Factors In Newly Diagnosed Type2Diabetes Mellitus

Objective:To understand the feature of hs-CRP levels and skeletal muscleintramyocellular lipid in newly diagnosed type2diabetes mellitus(T2DM). Toinvestigate the relationship between hs-CRP and skeletal muscleintramyocellular lipid and influencing factors on hs-CRP, provide support in thestudy of skeletal muscle intramyocellular lipid deposition mechanism ofinflammation.Methods: Thirty-four patients of T2DM were included in the case group and17healthy volunteers were in the control group. Outcomes measured were height, weight,waist circumference, hip circumference, heart rate, systolic blood pressure(SBP), diastolic blood pressure(DBP), fasting blood glucose(FBG), fastinginsulin(FINS), glycosylated hemoglobin(HbA1C), total cholesterol(Tch),triglycerides(TG), high-density lipoprotein(HDL-C), low density lipoprotein (LDL-C), high-sensitivity c-reactive protein(hs-CRP) etc. Using MagneticResonance Spectrum analysis(Magnetic Resonance Spectrum, MRS)determination intramyocellular lipid(IMCL) content of right calf soleusskeletal muscle. Body mass index(BMI), waist hip ratio(WHR) and Homeostasismodel of assessment for insulin resistance index(HOMA-IR) were calculated.. All_of the statistical data is to mean±SD（X±S）, T2DM group and the controlgroup the indicators compared with t test. T2DM group hs-CRP, soleus IMCLand the correlation between the indicators used Pearson correlation analysis, P <0.05think the difference were statistically significant. Twelve patients were furtherdivided into the intensive treatment group and undertook the education intervention fordiet and exercises, and all observation indicators of these patients were re-detected afterone month. Comparing the indicators before and after treatment, with matching ttest. All of the statistical data was processed with SPSS16.0statistical software.Results:1.Age, gender and heart rate of two groups showed no statisticaldifference (P>0.05), Blood pressure, BMI, WHR, FBG, FINS, HbA1C, Tch, TG,LDL-C, HOMA-IR, hs-CRP and soleus IMCL of the T2DM group were all higherthan those of the normal control group (P <0.05), while HDL-C of the patient groupwas lower than that of the normal control group (P <0.05).2. Correlation analysis results showed that inflammatory factors hs-CRPwas significantly positively correlated with BMI, FINS, HbA1C, TG, HOMA-IR,soleus IMCL positively(P<0.05), but no correlation with WHR, FPG, Tch, LDL-C, HDL-C was found(P>0.05). Soleus IMCL was significantly positivelycorrelated with FINS, hs-CRP and HOMA-IR(P<0.05), however, no correlationwith FBG, HbA1C, the shape parameter BMI, WHR, and blood lipid metabolismindex (Tch, TG, LDL-C, HDL-C) was found(P>0.05).3. Heart rate slow down, BMI, FPG, HbA1C, Tch, TG reduce obviouslythan before, insulin resistance improved significantly, inflammation factorhs-CRP significantly decreased after intensive treatment than before(P<0.05), whileSBP, DBP, WHR, FINS, LDL-C, HDL-C and soleus IMCL showed nosignificant change (P>0.05).Conclusion:1. The newly diagnosed T2DM patients have increased chronicinflammatory factor hs-CRP levels, HOMA-IR and skeletal muscleintramyocellular lipid.2. Hs-CRP and skeletal muscle intramyocellular lipidcontent in newly diagnosed T2DM patients are closely related.3. Moreover, afterthe diet and exercise treatment for a month hs-CRP levels have significantly decreasedin T2DM patients, but the skeletal muscle intramyocellular lipid can’t reduce in a shortterm. The results of impact factor needs further research..