Calcaneal Quantitative Ultarsound Bone Mineral Density And Analysis Of Its Related Factors In290Patients Of Maintaining Hemodialysis

Objective: The purpose of this research is to do cross-sectional studyabout calcaneal quantitative ultrasound bone mineral density and itsrelated factors in patients of maintaining hemodialysis.Methodology:290patients in dialysis centers in the Second Hospital ofJilin University were selected for studying group and90healthy peoplewere selected in control group.Gender,age,height,weight,body mass index(BMI) of380subjects were recorded,calcaneus BMD was measured byultrasound bone densitometer.Duration of dialysis,primary disease ofchronic renal insufficiency were recorded as well.Serum intactparathyroid hormone (iPTH),calcium, phosphorus,and calcium-phosphateproduct were assayed.SPSS13.0was applicated for statistical analysis.Results: BMD of MHD patients was significantly lower than controlgroup (P<0.01).Among the MHD patients,BMD of female wassignificantly lower than men (P<0.01).Calcaneal ultrasound BMD hassignificant negative correlation with age (r=-0.387,P<0.01), duration ofdialysis (r=-0.150,P<0.05),and it has significant positive correlation withheight (r=0.349,P<0.01),weight (r=0.250,P<0.01),serum phosphorus(r=0.184,P<0.05),and it has no correlation with serum calcium,calcium-phosphate product and BMI.BMD of primary chronicinterstitial nephritis group was significantly lower than the diabeticnephropathy group (P<0.05) and chronic glomerulonephritis group(P<0.01), as well as benign small arterial renal sclerosis group (P<0.05).There was no significant difference (P>0.05) of BMD between diabeticnephropathy and non-diabetic nephropathy.Conclusion: BMD of MHD patients was significantly lower than healthypeople,and with the extension of duration of dialysis, BMD would reducefurther.Female,advanced age, short stature, low dry weight,hypophosphatemia,primary chronic interstitial nephritis were risk factorsof osteoporosis for the MHD patients.