Studies On Factors Of Compatible Stability Of Potassium Dehydroandrograpolide Succinate For Injection And Relative Drugs

Object:To investigate the stability of compatibility about Potassium Dehydroandrograpolide Succinate for Injection (PDSI) respectively with Vitamin B6Injection (VBI), Levofloxacine Hydrochloride Injection (LHI), Clindamycin Hydrochloride Inje-ction (CHI) in different conditions, at the same time, to study the compatibility situation of the above drugs in vitro blood.Method:Using ultraviolet spectrophotometry to observe compatibility liquid color appearance, pH, UV spectrum and absor-bance values changes after Potassium Dehydroandrograpolide Succinate for Injection (PDSI) respectively combine with Vitamin B6’ Injection (VBI), Levofloxacine Hydrochloride Injection (LHI), clindamycin hydrochloride injection (CHI) in different manufactures, different temperature, different light, different compatibility order. Using high performance liquid chromatography (HPLC) determinate the Potassium Dehydroandrograpolide Succinate for Injection (PDSI), chromatographic column in vitro blood, whose mobile phase was0.05%phosphate buffer solution (pH adjusted with phosphoric acid)-methanol (40:60), the flow rate was1.0ml/min, and the detection wavelength was253nm, and to compare the content of Potassium Dehydroandrograpolide Succinate for Injection (PDSI) whether had significant difference or not before the combination and after the combination.results:By observing the changes of UV, spectrum and the content, we know after respectively compatibility of the Potassium Dehydroandrograpolide Succinate for Injection (PDSI) with Vitamin B6Injection (VBI), Levofloxacine Hydrochloride Injection (LHI), Clindamycin Hydrochloride Injection (CHI) compatibility, ts appearance, pH, UV spectrum and absorbance values are obviously changed, so there is incompatibility;also by high performance liquid chromatography (HPLC) determination of in vitro blood with Potassium Dehydroandrograpolide Succinate for Injection (PDSI) content,the compatibility Potassium Dehydroandrograpolide Succinate for Injection (PDSI) were significantly decreased even became no existed.Conclusion:Potassium Dehydroandrograpolide Succinate for Injection (PDSI) respectivelycompatibilityVitamin B6Injection (VBI), Levofloxacine Hydrochloride Injection (LHI), Clindamycin Hydrochloride njection(CHI)have n compatibility n above conditions, and the other three drugs make obvious effect on Potassium Dehydroandrograpolide Succinate for Injection (PDSI) absorbance in vitro blood, in order to ensure clinical medication safety, Potassium Dehydroandrograpolide Succinate for Injection (PDSI) is prohibited to combine with the above-mentioned three kinds of drugs in infusion process.