Objective:To study the effect of Buyang Huanwu Decoction on sensory function restoration after replantation of amputated finger. To investigate the active mechanism of Buyang Huanwu Decoction on promoting sensory nerve regeneration from the perspective of traditional Chinese medicine and western medicine. It may provide a new therapy method to functional improvement of peripheral nerve injury.Methods:40patients with replantation of amputated finger were selected between the January2013to June2013in the Wendeng Osteopath Hospital of Shandong Province, divided into treatment group and control group. There was no statistically significant difference between them in age, time of injury, etc. The patients in the two groups were given conventional therapy. In addition, the patients in the treatment group were received oral intake of Buyang Huanwu Decoction. The therapeutic time was12weeks. The sensation level and two points discrimination were examined at the end of the third and sixth month postoperative. Six months later, date was collected for statistical analysis, and the clinical efficacy and safety were evaluated in the prospective self-controlled study.Results:Buyang Huanwu Decoction has significant effects in promoting sensory nerve regeneration.There was statistically significant difference in the improvement of sensory function between the two group on the third month(P<0.05).2fingers in control group reached to S3+on the sixth month, while11fingers did in the therapy group. Effect on therapy group was better than that in control group. Simultaneously there was statistically significant difference in the improvement of2-PD between the therapy and control group (P<0.05).Conclusion:Buyang Huanwu Decoction is effective and safe in promoting sensory nerve regeneration after replantation of amputated finger. It is not the most specific drug, while Buyang Huanwu Decoction can accelerate the restoration of sensation and motor. This prescription has the advantages of rich supply, satisfying clinical efficacy, few side effects. It is an ideal and suitable therapeutic way to sensory function restoration after replantation of amputated finger, and has broad prospects for development and application in clinical practice. |