The Study On The Relationship Of TMPRSS2-ERG And Bcl-2Gene In The Tissue Of Prostate Cancer And The Clinical Significance

Objective:To study the relationship of positive expression rates between bcl-2and TMPRSS2-ERG, and their correlation with pathological classification of prostate cancer, to further investigate pathogenesis of prostate cancer, change of the molecular biology and interaction between cancers. Methods:A total of58pathological specimen of prostate cancer were selected, with55for detecting bcl-2expressions by immune histochemical method, and with3as the control. Then detect TMPRSS2-ERG expression of30cases randomly selected from the55specimen, the detection results were analyzed for the correlation between the two genes and their relationship with pathological classification of prostate cancer. Results:The positive rates of bcl-2(72.73%, n=40) showed no significant difference with cancer classification among the low, middle and high differentiated groups (Chi-square0.636, p=0.728).The intensity differences of bcl-2positive expression showed no statistical significance (Chi-squarel.465,p=0.962); the positive rates of TMPRSS2-ERG (53.33%, n=16) showed no significant difference with cancer classification among the low, middle and high differentiated groups (Chi-square0.158, p=0.924). Of the30 cases tested for positive expression rates suggests a significant correlation between both the TMPRSS2-ERG and bcl-2with r=0.494(p=0.006). Conclusion:1) the positive expression rate and expression intensity of bcl-2in prostate tissue have nothing to do with pathologic grading.2) Positive expression rate of TMPRSS2-ERG has nothing to do with pathologic grading.3) The expression rate of bcl-2is associated closely with TMPRSS2-ERG in prostate cancer tissues, affecting and promoting each other in pathogenesis of prostate cancer.16Charts,5forms,69references...