The Relationship Between Serum ABCA1Levels And Coronary Stenosis And Collateral Circulation Formation

Objective:To investigate the relationship between ATP binding cassette transport protein A1(ABCAl) levels and the severity of coronary heart disease, and the relationship between ABCA1levels and coronary collateral circulation formation in patients with coronary heart disease.Method:106patients who accepted coronary angiography during2012July and2012December in cardiac catheterization laboratory of Xiangya Hospital were randomly selected, including75cases with coronary heart disease and31cases normal control. The serum ABCA1concentration were detected by using ELISA method; the severity of coronary artery disease were evaluated in application of Gensini score; the formation of coronary collateral circulation were assessed by the Rentrop classification method.Results:1.The results showed the concentration level of serum ABCA1(6.46±1.26ng/ml) in normal control group was significantly higher than that in patients with coronary heart disease (4.62±0.95ng/ml), the difference was statistically significant (P<0.05).2. Gensini score≥50was classified as severe group, and Gensini score<50was classified as mild group. We found that the concentration level of serum ABCA1in mild group (5.06±1.15ng/ml) was significantly higher than that in patients with severe coronary heart disease (4.09±0.89ng/ml)(P<0.05). Correlation analysis showed that the concentration of serum ABCA1and the Gensini score of coronary heart disease was negatively correlated.3. The collateral circulation formation was observed in severe stenosis group by using the Rentrop classification method, and the results showed that26of the32patients formed collateral circulation, with a rate of81.25%, including14cases with bad formation (grade0and1) and12cases with good formation (grade3and4). The concentration level of serum ABCA1in the good-formed group (4.19± 1.12ng/ml) was significantly higher than that in the bad-formed group (3.22±0.80ng/ml)(P<0.05). Correlation analysis showed that the concentration of serum ABCA1and the collateral circulation formation was positively correlated.Conclusion:1.The concentration of serum ABCA1in patients with coronary heart disease was significantly decreased and was negatively correlated with the severity of coronary heart disease.2. The concentration of serum ABCA1in patients with severe coronary artery stenosis was positively correlated with the collateral circulation formation.