| Objective1.To discuss the brachial artery endothelial function of the long-term drinkers byhigh frequency ultrasonography.2.To discuss the correlation between the brachial artery endothelial function andleft ventricular diastolic function in the long-term drinkers by ultrasonography.MethodsEighty chronic alcohol abusers were divided into3groups:groupB(n=30):consumed2to3bottles(1100～1650ml) of beer or≥90g ethanol daily for5to8years,3to5days per week;group C(n=25):consumed2to3bottles(1100～1650ml)of beer or≥90g ethanol daily for9to20years,3to5days per week;groupD(n=25):consumed≥4bottles(≥2200ml) of beer or≥150g ethanol daily for more than10years,6to7days per week.Group A(n=30):the control group.High frequencyultrasonography was applied to measure the diameter of the brachial artery during restand reactive hyperemia,and the EDD of the brachial artery was calculated QTVI wasapplied to detect early peak systolic velocity(Ve),atriarl contraction(Va) andVe/Va.Then calculated average Ve,average Va and average Ve/Va.Results1.EDD was significantly lower in group C and group D than that of group A andgroup B(P<0.01).EDD was significantly lower in group D than that of the group C(P<0.01).2.Average Va was significantly higher in group C and group D than that of groupA and group B(P<0.01),average Ve and average Ve/Va were significantly lower ingroup C and group D than that of group A and group B (P<0.01).Average Ve was lower in group D than that of the group C (P<0.05),but average Va and average Ve/Vashowed no change significantly(P>0.05).there was no significantly difference betweengroup A and group B.Correlation analysis showed that the EDD was positivelycorrelated with average Ve and average Ve/Va (P<0.01).Conclusion1.High frequency ultrasonography can assess accurately the brachial arteryendothelial function of the long-term drinkers.2.The disorders of the brachial artery endothelial function may related closely withleft ventricular diastolic disfunction in the long-term drinkers. |
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