| Objective: To detect the visual pathways of normal and optic nerve injury ratsusing in vivo manganese-enhanced MRI, seeking new methods for optic nerve injurydiagnosis,monitoring,and drug efficacy evaluation.Methods:18wistar rats were randomly divided into2groups, each group ofnine.The two groups are normal control group and optic nerve injury group.Group1was normal control group,and group2was optic nerve injury group.The rats of normalcontrol group were subjected to no handling. The rats of optic nerve injury group weresubjected to optic nerve injury.The position of optic nerve injury was2mm away fromthe lamina cribrosa.The right eyes of all the animals were experiment eyes. In the13thday after the model of optic nerve injury were made,the right eye of every animal ineach group was subjected to intravitreal injection with2ul of25mM MnCl2.MRIexamination was performed24hours later.Results: Normal control group present obvious manganese enhanced signal fromthe retina to the superior colliculus, however, optic nerve injury group only presentobvious enhanced signal in retinal area. The signal-to-noise ratio differences betweenthe two groups have statistical significance.Conclusions: Manganese enhanced MRI is a feasible method of optic nerve injurydetection.It is expected to provide effective imageology evidences for optic nerveinjury diagnosis,monitoring,and drug efficacy evaluation. |
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