The Study On The Correlation Between The Indicators Of Coronary Artery Calcification And The Degree Of Stenosis By Use Of Dual-source CT

ObjectiveTo study the relationship of various parameters of Coronary artery calcification(CAC) and the degree of coronary artery stenosis, to research the availability ofevaluating the degree of coronary artery stenosis through using various CACparameters.MethodsRetrospectively analyzed the DSCT scanned data of142suspected coronary heartdisease patients from February2010to March2013, including images of coronaryartery CT angiography (CTA) by dual-source CT and related CAC parameters, throughmultiple variance analysis and multiple regression statistical analysis, compared therelationship of coronary artery LCX, LM, LAD, RCA and total CAC related parameterswith the degree of related blood vessel stenosis for all cases.ResultsThe index of CAC numbers, CAC volume, CAC equivalent mass and CACS ispositive correlation with coronary artery stenosis. The incidence of LM stenosis was9%,the incidence rate of severe stenosis of about1%among them. The incidence of CX,LAD, RCA stenosis rate were26%,51%and31%, the incidence of severe stenosiswere5%,15%,4%. We found the incidence of CAC and the severe situation of degreeof stenosis of LM were significantly lower that of CX, LAD, RCA branch blood vessels, and the incidence of stenosis and severe stenosis of LAD were highest in the all branchblood vessels. We also found the parameters of CAC were significant different (P <0.05) in patients without coronary artery stenosis and patients with coronary arterystenosis, and also quite different in patients with coronary artery stenosis patients indifferent levels (0~3groups). Multiple regression analysis of CAC numbers had betterfitting degree than other CAC index. Age, hypertension, family history, smoking,drinking alcohol, diabetes, hyperlipidemia, abnormal ECG are the risk factors ofcoronary heart disease.ConclusionThe advantage of CAC analysis through DSCT is simple in operation and analysis,low cost, index sensitive and overcome the side effects and complications of contrastmedium.But CAC analysis has limitation, for patients without CAC or CAC in a lowerdegree, it is very difficult to exclude coronary heart disease only by CAC parameters ifthere are obvious coronary heart disease risk factors, the abnormal ECG especially STsegment change and typical clinical symptoms of patients. We can use coronary CTangiography for further examination, in order to avoid missed diagnosis andmisdiagnosis. But patients with above symptoms are very few, we can still use CACparameters for early diagnosis and screening.for the most majority of patients withcoronary artery disease or no obvious symptoms of potential patients with coronaryheart disease.