Therapeutic Effects Observation Of L-carnitine On Duchenne/Becker Muscular Dystrophy

Background: Duchenne/Becker muscular dystrophy is a kind ofprimary progressive skeletal muscle disease caused by a genetic defect.There is no can completely cure, classic drugs such as hormone therapy candelay the progression of children, but has great side effects.Objective: To observe the therapeutic effects of L-carnitine onDuchenne/Becker muscular dystrophy(PMD) and its affect on improvingthe patients`life quality. Then it can provide the directions on its clinicalusing.Methods:1. Collected the children who were clinical diagnosed withprogressive muscular dystrophy in Children’s Hospital of ChongqingMedical University during2012, a total of26cases. And divide them intotwo groups according to whether taking L-carnitine.2. Ask the childrencome to have a check on their serum muscle enzyme every two months, andfollowed up for4months in total; Ask the patients and their guardian finishthe PedsQLTM4.0when the first and the third time they come.3. To recordthe value of serum muscle enzyme and quality of life scores werestatistically analyzed.4. Analysis the physical functioning part in thePedsQLTM4.0 Result:1. There is a decrease in the serum enzymes after theexperimental group take the medicine, and the difference was statisticallysignificant (P <0.05).2. The CK, CK-MB and LDH decline rate ofexperimental group has a differences when compared to the control group,the differences are statistically significant (P <0.05).3. The PedsQLTMscores after medication of the experimental group also has a differencewhen compared to themselves before medication, but there was nostatistically significant difference (P>0.05).Conclusion:1.Oral L-carnitine can reduce the serum enzyme level ofthe DMD/BMD patients effectively.2. The decline rate is faster in the firsttwo month than it in the second two month.3. It`s no obvious improvementsof the life quality after taking L-carnitine for short-time.