| Objective: Progressive muscular dystrophy is a kind of family, hereditary diseases, the main clinical manifestations of the original random muscle degeneration, a progressive increase, is a disabled, and the high rate of fatal diseases. Clinical diagnosis of the disease mainly rely on the typical clinical manifestations, elevated serum enzymes, electromyography and muscle biopsy combined basis.PMD in the Flaccidity of TCM, the researches of which the past medicine investigators constantly reinforced and consummated that formed the whole diagnosis and treatment system relatively. The TCM which depent on clinic system was short of external standard. we use the way that combined TCM with western medicine to 83 patients of PMD with the type, grade, and laboratory diagnostic indicators of Syndrome Distribution of investigation and analysis, with a view to provide reference for the SyndromeMethods: Patients with progressive muscular dystrophy choosed from the second Hospital of Hebei Medical University,Department of Neurology, a total of 83 cases, patients with muscular dystrophy were selected accord with diagnostic criteria [1]. In accordance with the type of disease diagnostic criteria for classification. In accordance with the severity of the disease assessed after grade, divided into 5 types with normal, light, medium, heavy, very heavy. Serum enzyme testing, EMG, muscle pathology examinations, and the conduct of Chinese medicine and Chinese medicine-Proof of Slip-dialectical ,analysis of the relations between different types , grade,laboratory diagnostic indicators with the TCM.Results:1 The relation between types and symptom factors of disease nature:in the DMD type, the LGMD type and the FSHD type, The frequency of deficiency of Qi with the DMD type (45.94%) was significantly lower than that of the FSHD type (85.71% ), (P <0.01),and the frequency of deficiency of Yang with the DMD type(54.05%) was significantly higher than the latter (14.28%),(P<0.01). the frequency of phlegm syndrome with the DMD type (51.35%) were higher than those types of LGMD (20%) ,FSHD (9.52%), (P <0.01). DMD of the incidence of blood stasis (32.43%) was significantly higher than the FSHD type (P <0.01).2 the frequency of symptom factors of disease location among types(DMD, LGMD, FSHD): three types in renal and muscle ,the emergence of rate were all 100%, followed by a higher rate for the spleen, are more than 80%.Liver(under14%), lung(under33%) the emergence of the low rate. located in between the bones and tendons of the distribution, in addition to FSHD (19.04%) was significantly lower than the emergence of DMD group (81.08%), (P <0.01), in the remaining 3 groups there was no difference of the distribution (P> 0.05).3 Progressive muscular dystrophy disease classification and TCM relations:All patients with grade: The frequency of deficiency of Qi of gradeâ… (mild,100%),gradeâ…¡(moderate,95.45%), gradeâ…¢(severe,68%) was significantly higher than gradeâ…£(most severe,25%),(P<0.01). The frequency of deficiency of Yang, phlegm syndrome and blood stasis of gradeâ… (mild,0%;0%;0%),gradeâ…¡(moderate, 4.54%;0%;0%), gradeâ…¢(severe,32%,16%,0%)was significantly lower than the gradeâ…£(very severe75%;78.57%;50%),(P<0.01).DMD,LGMD and FSHD were graded according to severity of disease, the classification with TCM relations : the frequency of the deficiency of Qi gradually reduced in DMD and LGMD with the classification increased,(P<0.01),The frequency of deficiency of Qi with the FSHD, compared the incidence of discrimination at all levels, there was no difference. (Pï¹¥0.05).The frequency of deficiency of Yang , phlegm syndrome, blood stasis with the DMD increases gradually with the the classification increased in DMD(P<0.01).4 The relationship between TCM and Serum enzymes:in the DMD type,The deficiency of Yang Group, deficiency of Yin group, phlegm syndrome group, blood stasis group serum enzyme levels were significantly lower than deficiency of Qi group, deficiency of blood group (P <0.01).5 The relationship between TCM and motor unit potential: deficiency of Yang Group, deficiency of Yin group, phlegm syndrome group, and blood stasis group,motor units to shorten time and the diminution of amplitude was significantly lower than Deficiency of Qi, deficiency of blood syndrome group (P <0.01).Conclusions:1 The relation between types and symptom factors of disease nature: The frequency of deficiency of Qi with the DMD type was significantly lower than that of the FSHD type,and the frequency of deficiency of Yang with the DMD type was significantly higher than the latter. the frequency of phlegm syndrome with the DMD type were higher than those types of LGMD ,FSHD. DMD of the incidence of blood stasis was significantly higher than the FSHD type.2 the frequency of symptom factors of disease location among types(DMD, LGMD, FSHD): three types in renal and muscle ,the emergence of rate were all 100%, followed by a higher rate for the spleen, are more than 80%.Liver, lung the emergence of the low rate. located in between the bones and tendons of the distribution, in addition to FSHD was significantly lower than the emergence of DMD group, in the remaining 3 groups there was no difference of the distribution.3 Progressive muscular dystrophy disease classification and TCM relations: All patients with grade: The frequency of deficiency of Qi of gradeâ… (mild), gradeâ…¡(moderate),gradeâ…¢(severe) was significantly higher than gradeâ…£(most severe), the three groups ,The frequency of deficiency of Yang, phlegm syndrome, blood stasis was significantly lower than the incidence of gradeâ…£(very severe). DMD,LGMD and FSHD were graded according to severity of disease, the classification with TCM relations : the frequency of the deficiency of Qi gradually reduced in DMD and LGMD with the classification increased, The frequency of deficiency of Qi with the FSHD, compared the incidence of discrimination at all levels, there was no difference..The frequency of deficiency of Yang , phlegm syndrome, blood stasis with the DMD increases gradually with the the classification increased in DMD.4 The relationship between TCM and Serum enzymes:in the DMD type,The deficiency of Yang Group, deficiency of Yin group, phlegm syndrome group, blood stasis group serum enzyme levels were significantly lower than deficiency of Qi group, deficiency of blood group.5 The relationship between TCM and motor unit potential: deficiency of Yang Group, deficiency of Yin group, phlegm syndrome group, and blood stasis group,motor units to shorten time and the diminution of amplitude was significantly lower than Deficiency of Qi, deficiency of blood syndrome group For progressive muscular dystrophy type, classification, and laboratory indicators have some correlate with TCM, we can provide reference for clinical. |
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