Effectiveness Of Perioperative Oral Pregabalin On Chronic Postsurgical Pain After Radical Resection Of Lung Cancer

Purpose:To explore whether perioperative oral pregabalin could relieve chronic pain after radical resection of lung cancer.Methods:We performed a randomized, placebo-controlled study involving90cases (20-65years old, ASA Ⅰ-Ⅲ, prepared to receive elective radical resection of lung cancer). Patients were randomly divided into three groups. Group PP (n=30) was orally administrated pregabalin300mg2hours prior to surgery and150mg twice daily for5days after the surgery. Group P (n=30) used pregabalin300mg2hours prior to surgery and75mg twice daily for5days after the surgery. Group C (n=30) used placebo at the same time point with group A and B. Each patient was given patient controlled intravenous analgesia (PCIA) after surgery. Record the NRS score at the4,8,12,24,48,72,96,120h after surgery. Follow-up patients’occurrence and nature of pain at2,4and6months postoperatively.Results:1.There was no significant difference among three groups in patient characteristics and operative data including age, height, gender ratio, weight, operative time, postoperative radiotherapy and chemotherapy and postoperative NRS pain score (P>0.05);2. Static pain score and moving pain score (NRS) in group PP and P was lower than that in group C at2months postoperatively (P<0.05);3. There was no significant difference of static pain score among three groups at both4and6months postoperatively (P>0.05), however, moving pain score of group PP was lower than that in group C at4and6months postoperatively (P<0.05).4. Incidence of neuropathic pain was significantly lower at2months postoperatively in the pregabalin groups (group PP and P) compared with placebo group (group C)(P<0.05);5.There was no significant difference in the incidence of static pain or moving pain among three groups in6months postoperatively (P>0.05).Conclusion:Perioperative oral pregabalin with sufentanil PCIA can relieve static pain at2months postoperatively in patients with radical resection of lung cancer, can decrease the moving pain in6months postoperatively, can decrease the incidence of neuropathic pain at2months postoperatively, while can not decrease the incidence of static pain or moving pain in6months postoperatively.