| Objective: Extrauterine Growth Retardation （EUGR） refers to thepostnatal growth failure caused by various factors, which could lead to latergrowth failure and long-term consequences. There are many factors thatcould affect EUGR, and the main factor was inadequate nutrition intake.Recent years, many nutrition solutions have been issued related to preterminfant nutrition at home and abroad, but the incidence of EUGR is still high.The purpose of this article is to evaluate the nutrition intake and thepostnatal weight increase in very low birth weight infants during thehospital and identify the interrelated factors of postnatal weight increaseand extra-uterine growth retardation （EUGR） in VLBW infants.Methods: This was a retrospective review of infants admitted tohospital between7/10/2011and1/1/2013, eligible infants whose weightwas＜1500g at birth, admitted to Children’s Hospital of ChongqingMedical University within24hours of birth, survived for at least10daysand were free of major congenital anomalies. A total of59cases wereincluded according to this standard and the patient’s general situation, basic diseases, nutritional status and weight increase were retrospectivelyinvestigated in this paper; Infants were classified as IUGR （＜10thpercentile） based on weight for gestation at birth; classified as EUGR（＜10th percentile）based on weight for gestation at hospital discharge. Theinfants can be divided into EUGR and non-EUGR group. According tointrauterine growth rate, infants were divided into two groups, one wasweight growth quickly when the growth rate is more than15g. kg–1. d-1,another was weight growth slowly when the growth rate is less than15g.kg–1. d-1, compare the clinical features of two groups. The clinical dataare divided into measurement data and count data, The two-sample t-testwas used for measure data and chi-square test was used for count data.Results: There were59infants who met inclusion criteria. Theaverage birth gestational age was （221.63±15.17） d, the average birthweight was （1361.53±126.95） g, the average stay in hospital time was（34.03±14.65） d. the time to begin enter feeding was（1.85±1.83）d, therewere27infants that could achieve enough energy from enteral feeding, andthe average time was （25.62±11.85） d. the time to begin amino acids was（1.96±0.18）d, the starting dose was （1.23±0.45）g﹒kg-1. the time to beginLipid was （2.56±0.99）d, the initial dose was （0.92±0.37） g﹒kg-1. theaverage time of the total energy up to100kcal﹒kg-1﹒d-1was（19.87±12.49）d and the average time of the total energy up to120kcal﹒kg-1﹒d-1was（12.62±7.98）d. During hospitalization, there were15 infants that suffered from cholestasis disease （25.42%）; the average weightloss （4.28±2.88）%; the time of recovery to the average birth weight was（6.47±4.62） d. the average weight growth rate was （14.00±4.88） g.kg-1.d-1.In this paper, the incidence of intrauterine growth retardation was28.81%at birth, and the incidence of extrauterine growth retardation was79.66%atdischarge. In this article, infants in higher weight increase had less time ofenteral intake that was up to100kcal﹒kg-1﹒d-1and the total energy thatwas up to120kcal﹒kg-1﹒d-1; infants who developed EUGR hadsignificantly larger birth gestational age, and the time of the total energythat was up to120kcal﹒kg-1﹒d-1and recovery to the average birth weightwas longer. IUGR and anemia were more commonly found in EUGRinfants（P<0.05）.Conclusion: Most of the very low birth weight infants had problemswith nutritional deficiencies and growth failure during hospital stay, and theincidence of EUGR was still high. The major factors that affected weightincrease were inadequate nutrition intake. IUGE, and inadequate nutritionintake, the recovery of birth weight was the major factors that affectedEUGR. Early positive nutrition support might be beneficial to the growthof very low birth weight, and at a result, reduce the incidence of EUGR. |
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