The Study On Level Of Non-HDL-C And Cutoff Point For Indicating Metabolic Syndrome In Chinese Children And Adolescents

Objectives:This research aimed to study the level of non-high-density lipoprotein cholesterol (non-HDL-C) in Chinese children and adolescents, and look for the optimal abnormal cutoff point of non-HDL-C for metabolic syndrome (MetS) diagnosis.Methods:The data was collected from20039primary and middle school students (male10572, female9467) aged7～16y in6different areas around China, including Beijing, Tianjin, Hangzhou, Shanghai, Chongqing and Nanning. They were grouped according to the latest the definition of metabolic syndrome and prophylaxis and treatment proposal in Chinese children and adolescents published in2012. We compared the level of non-HDL-C for age, sex and BMI. Receiver Operator Characteristic Curve (ROC-curve) was generated in the analysis to help find the optimal cutoff point of non-HDL-C in those with MetS.Results:1. Draw out non-HDL-C concentrate level percentile chart of Chinese children and adolescents aged7～16y.2. Non-HDL-C concentrate level differs significantly for age, sex and BMI。 In those with MetS aged10～16y,the overall non-HDL-C concentrate was3.38±0.95mmol/L, corresponding to P90level in the distribution chart. ROC-curve analysis indicated that non-HDL-C has the best predictive effect at the point of2.73mmol/L, corresponding to P70level in the distribution chart. The sensitivity and specificity were respectively77.8%and71.6%.The Youden index was0.494and95%CI was0.782to0.832 Conclusions1. Non-HDL-C concentrate varied with age and sex and differed significantly for BMI.2. The prevalence of MetS was higher in obese children and adolescents aged10-16y with non-HDL-C concentrate over2.73mmol/L. The optimal threshold value of non-HDL-C concentrate was suggested to be3.38mmol/L in10～16y children and adolescents.