Expression Of Multimodality Therapies On Plasma Solube Tumor Necrosis Factor Receptor I In Obstructive Sleep Apnea Hyponea Syndrome Patients

Objectives:As a subtype membrane receptor of tumor necrosis factor-a,not much is known about the link between the soluble TNF receptor-I and Obstruct-ive sleep apnea-hypopnea syndrome.We hypothesized that the TNF receptor might play an important role in the inflammation in patients with OSAHS,moreover this study was undertakan to investigate the effects of multimodality therapies on its periphery blood level.Method:77adults with habitual snoring and mean age of34.9±llyears old consented to participate in the study.All participants were studied with overnight polysomnography,physical examination and a blood crew at baseline.According to the severity of OSAHS,they were categorized into three groups and one control group.moderate and severe OSAHS groups returned for a repeat test of polysom-nography and a blood crew at3months after the ENT surgery or continuous pos-itive airway pressure(CPAP).serum levels were measured by using an immunolu-minometric assay kit.Results:1.compared with control non-OSAHS group,serum sTNF-R I levels prior to treatment in OSAHS groups were significantly greater,with a mean serum levels at (742±258&340±102)pg/ml (p<0.05),respectively.2.Data from our study,there were differenses in the circulation levels of sTNF-R I between the fatter participants with a body mass index higher than28Kg/m2and the ones whose BMI lower than28Kg/m2.3. plasma solube tumor necrosis factor receptor-1responsed sensitiv-ely to the effect of comprehensive therapies when we compared its prior treatm-ent levels with post ones.the mean concentrations of serum sTNF-R I decressed by the levels of482±243pg/ml (p<0.05)4.Analysis was used to assess the associations adjusting for age, gender, BMI and weight,a positive assosiation were found between apnea-hypopnea index (AHI) and sTNF-R I (r=0.646,P=0.000) a negative assosiation were found between lowest nadir oxygen saturation (LSaO2) and sTNF-R I (r=-0.522,P=0.000)Conclusion:In summary, independent of age, gender, BMI and weight,our datas suggest a relationship between sTNF-R I and the severity of OSAHS.By the way of comprehend-sive therapies could attenuate the levels of serum sTNF-R I.This might imply that its necessary to ensure sTNF-R I make contribution to inflammation in OSAHS.moreover,it gives us physiological and clinical implications.