Clinical Study Of Auditory Event Related Potential P300in Non Dementia Cerebral Infarciton Patients With Cognition Impairment

Objective: To evaluate the diagnostic and therapeutic application of auditory eventrelated potential P300in cerebral infarction patients with non-dementia vascularcognitive impairmentMethod:91cerebral infarction patients with vascular cognitive impairment but not dementiawere recruited as study group, including45patients with cortical infarction,46patients withsub-cortical infarction, another45non-cerebral vascular cognitive impairment patients were alsoincluded as control group, P300, MMSE and MoCA were tested in all the study group subjectsbefore and after receiving treatment, the same were done with the control group. Gender, age, andeducational level were also evaluated. SPSS13.0statistical software is applied for statisticalanalysis, using analysis of variance for compard analysis, Post Hoc LSD test for pairwisecomparisons.Results: Before receiving treatment: compare to control group [latency (282.43±23.83ms) andamplitude (14.91±1.32μv)], results of auditory event-related potentials P300latency werestatistically significant (F=278.10, P <0.05) in patients with cortical cerebral infarction[latency(339.863±21.27ms) and amplitude (10.02±1.21μv)] as well as patients with subcorticalcerebral infarction [latency (262.66±243.84ms) and amplitude (10.62±0.93μv)]. The differencesof amplitude in3groups also reach statistically significant (F=113.15, P <0.05). patients withsubcortical infarction and those with cortical infarction have significant different P300latency whileamplitude were not significantly different. Both groups have lower scores of Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA)(P <0.05), but in terms ofnaming and verbal test, the difference was not statistically significant (P>0.05), Aater receivingtreatment, patients with cerebral infarction have shortened P300latency (P <0.05), and increasedcognitive scale score (P <0.05) than those in the control group, and changes difference in the studygroups was statistically significant (P<0.05); but scores of Mini-Mental State Examination (MMSE)and the Montreal Cognitive Assessment (MoCA) were not enhanced obviously, and changesdifference in the study groups was not statistically significant (P>0.05)Conclusion: patients with cerebral infarction have cognitive function impairment in early stage.ERP-P300test can objectively reflect cognitive dysfunction in VCI patients, with sensitivity higherthan traditional MMSE and MoCA measures.