| Objective The quality of life was an important indicator for evaluating the influenceof all kinds of diseases especially the chronic rheumatism disease on patients. Forpatients of chronic disease, the valuation of quality of life not only providedinformation of patients before treat and influence of physical, psychological andsocial function disease on patients, but also contributed to evaluating after treat effects.Our study tried to understand the status of the quality of life of patients withankylosing spondylitis, explored the possible influencing factors of quality of life inAS patients，and provided evidence for guiding the clinical treatment and evaluatingthe prognostic.Methods200patients including162men and38women with ankylosing spondylitiswere collected from Department of Rheumatism and Immunity, the First AffiliatedHospital of Anhui Medical University through cluster sampling methods.Epidemiological data of all AS patients was collected, including generalcharacteristics such as sex, age, nation, profession, exercise time per day, et al, BathAnkylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis DiseaseActivity Index. The quality of life was evaluated by SF-36scale, and the influencingfactors of quality of life were analyzed.Results compared with the general population, quality of life of AS patientsdecreased significantly; Analysis on general demographic factors of patients with ASshowed that scores of physiological functions (RP) and role emotional (RE) amongSF-36dimensions in female patients were higher than those of male patients, and thecomposite score of AS female patients was higher than that of male patients (P<0.05), the results showed that the quality of life of female patients with AS was better thanmale patients with AS. We divided occupation into two groups, and the results ofvariance analysis showed that scores of all dimensions had significant differencesamong the two groups on physical functioning (PF),vitality(VT),social functions（SF)and mental health（MH). The composite score among the groups showed that thequality of life of manual workers was worse than that of the other group.The diseasecourse was divided into less than or equal to one year, one to three years, three to fiveyears, five to seven years, and more than or equal to seven years. There werestatistically significant differences among scores of all dimensions in AS patients withdifferent course in addition to the VT and MH. The composite score showed that thelonger the duration, the worse the quality of life of the AS patients. AS patients weredivided into four groups including very optimistic group, optimistic group, generalgroup and feeling bad group based on their attitudes toward the prospects for thetreatment of this disease. There were statistically significant difference of scores ofgeneral health (GH), energy (VT), social function (SF), and mental health (MH) ofSF-36among these four groups. Pairwise comparisons of dimensions with significantdifference among the four groups showed that there were statistically significantdifference between very optimistic group and general group, very optimistic groupand feeling bad group, optimistic group and general group, and optimistic group andfeeling bad group. Score of energy (VT) had statistically significant differencebetween general group and feel bad group. The composite score indicated that theworse the mentality of AS patients toward the disease, the worse the quality of life.compared with the stability AS groups (BASDAI<4)，except vitality score andmental health score, the rest scores of active AS groups (BASDAI≥4) weresignificantly reduced, and the differences were statistically significant (P<0.05);compared to AS patients whose functional status is poor (BASFI≥5), except vitalityscore and mental health score，the rests of SF-36scores were higher in AS patientswhose functional status (BASFI<5) is good, and the difference was statisticallysignificant (P<0.05); Correlation analysis showed that Age, BASFI and BASDAI were found to benegatively correlated with the quality of life of patients with ankylosing spondylitis.BASFI and BASDAI were two influencing factors which were strongly correlatedwith SF-36subscale, and age was second to BASFI and BASDAI. Multivariateanalysis showed that treatment prospects, Bath AS disease activity inde(BASDAI)and BASDAI)，Bath AS functional inde(BASFI) might affect the quality of life ofpatients with AS (P<0.01), and ethnicity, religious beligious, economic income,average daily exercise time, smoking and drinking had no correlation with eachdimension of the SF-36.Conclusion The life quality of AS patients was most obviously lower compared to thehealthy person. For AS patients, the influence of disease on patients’ life qualitymight be more important, especially on the function states and disease activities.Publicity education about influencing factors of the life quality of AS patients andactive treatment was essential to improve the life quality of AS patients. |
PDF Full Text Request