Early Identification Of Impaired Renal Function In The Obese Children With Non-alcoholic Fatty Liver Disease

Objective:To early identify the impaired renal function in the obese children with non-alcoholic fatty liver disease (NAFLD).Methods:Three hundred and eighty-six obese children were enrolled and were divided into NAFLD group and simple obesity group (control group) according to the diagnostic criteria. Clinical biochemical parameters and early impaired renal functions were evaluated and compared. Further more, we subdivided234obese children with age over ten years into three groups:NAFLD combined with metabolic syndrome (NAFLD+MS) group, NAFLD group and simple obesity group (control group) to take the above indexes into comparison.Results:The urinary microalbumin of NAFLD group, NAFLD+MS group(over10years old), NAFLD group(overlO years old) are significantly higher than that of control which indicated that there existed early renal dysfunction in children with NAFLD and those accompanied with MS as well. Additionally, the positive correlation between urinary microalbumin and systolic pressure, triglyceride and2h-postprandial blood glucose were found, which demonstrated the role of hypertension glucose-lipid metabolic disorder in the pathogenesis of early impaired renal function and chronic kidney disease (CKD).Conclusions:NAFLD are not only an early sign of early impaired renal function but also an early stage of CKD in obese children. And their occurrence and development are significantly associated with hypertension、glucose-lipid metabolic disorder. As a result, early diagnosis and treatment of NAFLD is crucial for CKD prevention.