The Significance Of The Test For The CC16and SP-D In The Serum To The Patient Of COPD

Objective: In this study, we investigated the levels of SP-D and CC16in serum from acuteexacerbation of chronic obstructive pulmonary disease(AECOPD) group,stable phase group andNormal control group, and want to discuss the clinical significance of the SP-D and CC16expression in aspects of diagnosis, illness severity evaluation and prognosis of COPD.Method:33patients with COPD(evere exacerbation and stable stage) were randomly recruitedfrom Respiratory Medicine of First Affiliated Hospital Of The Medical College ShiheziUniversity,29healthy controls were recruited who did the physical examination in the centerclinic. We collected the serum from all the subjects. All subjects had taken lung functiondetection, main indicators like FEV1%(percentage of forced expiratory volume in firstsecond take in predicted value), FEV1/FVC%(forced expiratory volume in first second/forced vital capacity) and DLCO%(percentage of CO take in predicted value)are lower thannormal control group. We measured the level of SP-D and CC16by using ELISA.Result:(1)There was no difference in age,gender, smoking index and BMI among AECOPD,stable COPD and normal control group. But the level of FEV1%, FEV1/FVC%and DLCO%inCOPD group are low than normal control group.(2)The level of SP-D in AECOPD patient’sserum is (154.41±46.23)ng/ml, the level of SP-D in COPD stable phrase patient’s serum is(125.2±40.41)ng/ml, the level of SP-D in normal control group patient’s serum is (90.07±30.82)ng/ml,results significant difference between the three groups (P<0.05). The level of CC16inAECOPD patient’s serum is (65.93±29.70)ng/ml, the level of CC16in AECOPD patient’s serumis (93.45±42.65)ng/ml, the level of CC16in COPD stable phrase patient’s serum is(118.93±49.29)ng/ml, results significant difference between the three groups (P<0.05).Theresults suggest us that the level of SP-D and CC16is related to COPD, and COPD a systemicchronic inflammation disease（.3）The correlation analysis result showed that the level of SP-D inserum were negative associated with FEV1%(r=－0.609, P<0.01),and the level of SP-D in serumwere negative associated with DLCO%(r=－0.638P<0.01).The high level of SP-D in COPDpatient’s serum prompt his lung is serious damaged and lung function is significantly decreased.The level of CC16in serum were positive associated with FEV1%(r=0.568, P<0.01),this suggestus that low level of CC16prompt bad lung function.Conclusion:(1)COPD exacerbation of acute and stable level of serum SP-D significantly higherthan the control group, suggesting the air tube inflammation may worsened in AECOPD patients.The serum SP-D in COPD table level is lower, but is still higher than the control. The air tubeinflammation plays a relatively important role in the COPD.(2)COPD exacerbation of acute andstable level of serum CC16significantly lower than the control group. COPD table level ofserum CC16is lower than the control group. Dynamic Monitor the serum SP-D and CC16levelof COPD patients might not only reflect the body state of systemic inflammation but also reflectthe Severity of the disease. It can provide an effective basis for the clinical assessment oftreatment efficacy and prognosis.(3)SP-D and CC16level in serum of COPD can indirectlyreflect damage of lung and the seriousness of the condition. And it can lay the foundation fortreatment and rehabilitation.