Application Of Cystatin C In Renal Function Evaluation For Essential Hypertensive Patients

Objective：To investigate the diagnostic value of serum Cystatin C（Cys-C）in earlyrenal impairment of essential hypertension. Methods：From October2011to September2012, two hundred and thirteen essential hypertensive patients at the average age of(51.2±12.7) from the hypertension department of the First Affiliated Hospital of XinjiangMedical University were enrolled. According to the GFR levels, they were divided intothree groups: renal moderate and severe impairment group (GFR≤60mL/min), renal mildimpairment group(60<GFR<90mL/min),and normal renal functiongroup(GFR≥90mL/min). The correlation of Cys-C and GFR was analysed and the bestcut-off value of Cys-C in diagnosing early renal impairment of primary hypertensivepatients was calculated using ROC curve. Results：Creatinine and Cys-C in renalmoderate and severe impairment group were statistically higher than those in renal mildimpairment group and normal renal function group，Cys-C in renal mild impairmentgroup was statistically higher than those in normal renal function group，(all P＜0.05).GFR was negatively correlated with Cys-C（r=-0.320，P<0.01）. According to the ROCcurve, the best cut-off value of Cys-C was0.86mg/L in diagnosing early renal impairmentin primary hypertensive patients,with a sensitivity of62%and a specificity of60%, andthe area under ROC curve(95%CI) was0.643(0.558-0.722). Conclusion：Cys-C is oneof the important diagnostic indices for early renal impairment of essential hypertensivepatients.