Seroepidemiologic Study On The Infectious Status Of The Hepatitis B Virus In People Aged From1to59in Anhui Province In2006

Viral Hepatitis B, one of the most infectious diseases, is severely harmful to people’s health. In China, many families are stuck in the poverty because of it. And its influence on the social stability and economic development can not be avoided. The data of the china information system for disease control and prevention indicates that the annual reporting cases of viral Hepatitis B are at the top of37infectious disease.Since Hepatitis B vaccine(Hep B)was invented in1980s, Anhui Province made an integrated control strategy of taking vaccine injection as leading, and combining prevention and treatment. The government brought Hep B into Expanded Programme on Immunization (EPI) management in1992, then, it was brought into EPI in2002. By adjusting the Hep B vaccine immunity strategy, the Hep B vaccine coverage rate has been increasingly improved.In1992, Anhui Province made an investigation of Hepatitis B Serum in the whole province. And the results were that aged from1to59, the adjusted positive rate of HBsAg was7.74%,and the Hep B virus infection rate was60.37%. In order to master infectious status of Hep B among aged from1to59, evaluate the effect of Hep B vaccine immunity strategy and offer scientific basis to adjustment of viral Hep B prevention strategy, the investigation was carried out.Objective To master the epidemic status of Hepatitis B virus infection, aging from1to59, in Anhui province in2006, and evaluate the effect of Hepatitis B Vaccine after it incorporated into EPI. Methods By taking multi-stage random sampling method,extract2726samples in12investigation points throughout6counties (cities, districts), aging from1to59, in Anhui Province.Questionnaires and2-4ml vein blood were collected from the2726individuals.Enzyme linked immunosorbent assay (ELISA) was used to detect HBsAg, HBsAb, HBcAb, HBeAg.Results In2006,Aging from1to59,adjusted positive rate of HBsAg, anti-HBs and Hepatitis B virus(HBV) infection were6.57%,53.81%and52.57%, respectively. Aaging from1to59, the vaccination rate of Hepatitis B vaccine was51.25%.To specifically, aging from1to4,5to14and15to19,the vaccination rate of hepatitis B vaccine were99.23%,83.90%, andl4.35%, respectively.Conclusion Compared with the investigation of seroepidemiology in1992, the characteristic of viral Hep B has changed in aged from1to59. And the positive rate of HBsAg is on the decrease, especially in the population aged from1to14.Hovere, the peak rate disappeared in aged from1to2. And in aged from20to39, the positive rate is almost same with the results of1992. And from30to39,the peak rate postponed to40to49. And the positive rate difference between village and town is meaningless in statistics. the effect of Hep B vaccine strategy played important role in improving the vaccination rate of hepatitis B vaccine and reducing the Hep B virus infection rate and protecting susceptible people. On the basis of keeping high vaccination rate of hepatitis B vaccine, We should improve the othe crowd vaccination rate of hepatiti B, especially farmers and doctors etc.