A Preliminary Study Of Patients With Type2Diabetes Changes In Thyroid Function

Objective1.TO Analyse the characteristics of prevalence of thyroid diseasein patients with type2diabetes.2. Explore the relationship of the differentTSH levels of blood pressure, blood lipids, BMI and blood sugar in patients withtype2diabetes.3. Through the Analysis of serum TSH, FT3, FT4changes, furtherexplored to the clinical features of type2diabetic patients withHypothyroidism.Methods To select211T2DM Patients who stayed in the Endocrinologydepartment of First People’s Hospital of Yinchuan City from December in2011to December in2012,among which113were male Patients and98were female. Wetested their height,body weight,blood pressure,body mass index(BMI),and Fastingblood glucose(FBG),glyeosylated hemoglobin A1c(HbA1c),serum totalcholesterol(TC),triglycerides(TG),and thyroid hormones free triiodothy-ronine(FT3),free thyroxine(FT4),stimulating hormone(TSH) by standardlaboratory techniques. The outcomes were then statistically analyzed withSPSS16.0.Results1. Thyroid disease prevalence rate with211cases type2diabetes patientswas9.95%. Female prevalence rate was13.27%, male prevalence rate was7.08%,the difference between the two groups was not statistically significant (P＞0.05). The prevalence rate of clinical hyperthyroidism was2.84%, the prevalence rate of clinical Hypothyroidism was0.88%, the subclinical hyperthyroidismprevalence rate was0.88%, the prevalence rate of subclinical hypothyroidismWas6.16%. The prevalence of Women with subclinical Hypothyroidism was10.20%,which was significantly higher than other thyroid disease group (X~2=4.556,P＜0.05).2. The number of Type2diabetic patients under different levels in the normalrange of the TSH0.3-5.5uIu/ml had a significant difference each other(X~2=13.534,P＜0.001), and an increasing trend to increase the number of patients with TSHconcentration.3. The levels of Body mass index (BMI) with type2diabetes patients wereincreased with TSH levels,the difference was statistically significant (P＜0.05). Compared with group TSH1.0-1.99uIu/ml, the fasting plasma glucose levels(FGB) of group TSH0.3-1.0uIu/ml and group TSH2-5.5uIu/ml were significantlyreduced. The difference was statistically significant (P＜0.05). TSH levelincreased with the patient’s age, duration, but the differences among thegroups was not statistically significant (P＞0.05). The patient’s systolic bloodpressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), cholesterol(TC) level increased with TSH levels, but the differences among the groups wasnot statistically significant (P＞0.05).4. The FT3, FT4levels of TSH <0.3uIu/ml groups were significantly higherthan other groups, the difference were statistically significant (P＞0.05). TheTSH0.3-0.99uIu/ml group FT4levels were significantly higher than the TSH>5.5uIu/ml group, the difference was statistically significant (P <0.05).5. To estimated211cases type2diabetes patients interquartile, the FT4upper quartile in20.65pmol/l, the lower quartile in14.93pmol/l; the FT3upper quartile in6.06pmol/l, the lower quartile in4.1pmol/l. Patients within the normal reference range in TSH0.3-5.5uIu/l, FT4upper quartile of TSH levelssignificantly below the lower quartile TSH levels, the difference wasstatistically significant (P <0.05). FT3upper quartile group, FT3lowerquartile group and between groups was no significant difference (P>0.05) TSHlevels.6.211patients with type2diabetes in patients with TSH levels FT3, FT4,FGB, the HbA1c negative correlation with FT3, FT4negative correlation wasstatistically significant (P <0.05). TSH levels with age, disease duration, SBP,DBP, BMI, TC, TG positively correlated with SBP, DBP, BMI levels, a positivecorrelation was statistically significant (P <0.05).Conclusion1. The prevalence of type2diabetes in women with subclinical Hypothyroidismwere significantly higher than other thyroid diseases.2.The Thyroid function of Patients with type2diabetes is presented toreduce the trend.3. Different concentrations of serum TSH levels in type2diabetes patientswith blood pressure, blood lipids, BMI and blood sugar will produce differenteffects. Therefore, when a patient’s serum TSH is always low or high specificreference range, clinicians should carefully evaluate whether the patient withabnormal thyroid function.4. In type2diabetes mellitus thyroid function in patients with reduced partof the same hypothalamic and pituitary dysfunction. Consider the long-term poorglycemic control resulting in the hypothalamus, pituitary function affectedrelated with these patients.