| Background:Cough variant asthma (CVA) is a disease which solely nonproductive presents cough that is relieved with bronchodilators, and especially in the morning or at night. It is popular in spring. The patients always have allergic diseases or the family history at the same time. And about35.71%CVA may be developed classical asthma. The pathophysiology of cough variant asthma is poorly understood. Almost experts believe that CVA has the same pathophysiology as classical asthma--bronchial hyper responsiveness, airway inflammation and reversible restrained breath. CVA is treated with bronchodilator, steroid, Leukotriene receptor antagonist, aminophylline. The issue of the steroid is highly controversial. And the rest drugs always need patients take them for a long time, children with CVA is difficult to stick with it and long-term drugs taking has the side effects at the same time. Traditional Chinese medicine (TCM) has the advantages of treating CVA---good efficacy and few side effects. Old Chinese medical books do not have the name of CVA. According to its major clinical manifestation, some experts consider CVA has the same pathogenesis as CA-expathogenic factors acting on endopathic factors. It is different with common chronic cough for it often triggered by exercise, cold air, and common cold and so on. So it named "whooping cough","cough spasm","wind cough" in TCM. And treat is with the method dispelling pathogenic wind, eliminating phlegm, freeing lung, relieving asthma. And they have good efficacy by herbs internal or external. But some of them cannot totally recover after a series of TCM or west medicine treatment. Some of the rest children are always triggered by cold air, with the symptoms of cold extremities, or plump tongue and some cold manifestation. Tutor Yin Dan use the method of warming Lung and Eliminating Phlegm Invigorate Blood Circulation to treat the rest children with CVA, and gets good efficacy in clinical.Objective:In theory, this study refers to the papers about CVA, and gets the newest information on CVA. This study was designed to identify the effectiveness of the method of warming Lung and Eliminating Phlegm Invigorate Blood Circulation in the treatment of children CVA and to show clinical advantages of the TCM in a scientific method.Method:After a8-month run in period,37patients with diagnosed CVA and belonged to Hanyin Fufei type, in Beijing University of TCM learns first subsidiary hospital pediatrics outpatient, were assigned to receive treatment by oral herbs soups for14days. The youngest, the eldest and the average age is2years,8years old and (4.05±1.73) years respectively. Primary outcome measures were cough and phlegm symptoms and secondary outcome were TCM symptoms like i tchy throat, runny nose, sweating, cold extremities, pale, thirsty, tongue, and pulse and so on. And record their changes of symptoms before and after treatment7th and14th day.Result:Treatment with the method decreased primary and secondary scores, where the changes from baseline values were significantly greater than treatment before at the7th. And the scores of the14th are much better than the7"’. At the7th,2cases clinical recovery,8cases get the excellent results, and23cases prove effective, effective rate89.19%. At the14th,20cases clinical recovery, ll cases get the excellent results, and4cases prove effective, effective rate94.59%.Conclusion:This study showed the method of warming Lung and Eliminating Phlegm Invigorate Blood Circulation had great properties helping with cough and phlegm. |
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