Chinese Medicine Inside And Outside The Us For Joint Azithromycin Treatment Of Children Mycoplasma Pneumonia Clinical Research

Purpose Observe the clinical effect of internal and external application of Chinese herbal medication combined with Azythromycin for MPP and discuss the mechanism,through the comparison of the treatment of Azythromycin and the decoction of TCM ’haoqinmaxingshigantang’ combined with external treatment of TCM ’fuxiongsan’ which adds the pure treatment of Azythromycin for MPP of wind-heat-closed-plumonary-syndrome and phlegm-heat-closed-plumonary-syndrome.Methods This study collects50cases,who received clinical or hospital care in the Eastern Hospital of Beijing traditional Chinese medicine University, according with Western medicine diagnostic standard of mycoplasma pneumonia in children and belonging to TCM syndrome of wind-heat and phlegm-heat. Be randomly divided into treatment group and control group every25cases. Control group mainly to Azithromycin and symptomatic treatment; treatment group the decoction of TCM ’haoqinmaxingshigantang’ combined with external treatment of TCM ’fuxiongsan’ on the basis of control group treatment. Observe the clinical effect of internal and external application of Chinese herbal medication combined with Azythromycin for MPP, through the comparison of two groups of wind-heat and phlegm-heat type main indicators before and after the treatment (asthma, lung auscultation, cough, sputum indicates, fever, chest radiograph), secondary index (spirit, complexion, heart rate, appetite, nausea or vomit, thirst), laboratory indexes and curative effect evaluation. Discuss the effect of internal and external Chinese traditional medicine, which is based on affecting the changes of gene expression in IL-4and IFN-γ or not, by determination of two groups of patients before and after treatment levels of IL-4and IFN-γ in serum.Results Before and after treatment, there are significant statistics differences in the two groups, in the total integral, primary symptoms (e. g, asthma, sputum, cough, fever), primary symptom integral, secondary symptoms (such as heart rate, appetite, nausea or vomit, thirst), and secondary symptom integral. After treatment between the two groups, there are statistics differences in the total score, cough, sputum, lung auscultation, fever, primary symptom integral, appetite, secondary symptom integral and efficacy evaluation; there is no statistics diffcrencc in asthma, chest radiograph, spirit, complexion, heart rate, thirst, treatment and effect of grading. Before and after treatment, there is no statistics difference in the two groups, in laboratory examination indexes, IL-4, IFN-r and IL-4/IFN-rConclusions Compared with the pure treatment of Azythromycin, the decoction of TCM ’haoqinmaxingshigantang’ combined with external treatment of TCM ’fuxiongsan’ which adds the treatment of Azythromycin, has obvious advantages of general curative effect (such as evaluation of curative effect, the total integral, primary symptom integral, disease classification), symptom improvement (primary symptom, such as cough, sputum, lung auscultation, fever; secondary symptom, such as appetite)and a tendency of reducing treatment, for MPP chidrenaccording with TCM syndrome of phlegm-heat. The protocol is effective, safe, and there is no obvious adverse reactions. The treatment of internal and external application of Chinese herbal medication combined with Azythromycin for MPP according with TCM syndrome of wind-heat and phlegm-heat, has a curative effect, which is worth promoting.