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Based On Fmri Research Of The Relativity Of Brain Movement Function And Age

Posted on:2013-10-10Degree:MasterType:Thesis
Country:ChinaCandidate:F F YanFull Text:PDF
GTID:2244330395452481Subject:Education Technology
Abstract/Summary:PDF Full Text Request
As we moving into the "silver-haired" society, the brain aging problem has become an important socio-economic problem. Research shows that the brain aging problem not only reflect in the changes of brain weight and volume, density and thickness of gray matter, dispersion rate and part anisotropy values and other indicators of white matter, but also reflect in some changes in the functions of the brain cortex. However, the changes are non-linear variation because of the influence of age, learning, training or other factors. The brain structure and function will be dynamic repair and recombination. The degradation of the function caused by the aging is very broad-spectrum, involving almost all cognitive functions, on sports, it reflects in slow motion, balance ability to drop, agility decline, thus it severely affects our life and learning. The purpose of this research is to explore how the cortical motor function area, which is closely linked with movements, changes with age.This article was based on complex finger motor as experimental model, and the data was from the ICBM database. We used generalized linear models and the one-sample T-test model to analyze the differences of the motor function areas between young group and old group. Firstly, the format of fMRl brain images should be converted in order to be identified by other softs. And then considered their own characteristics, we chose the suitable sequence of preprocessing. The steps consisted of time slicing, realign, normalization and smoothing. Finally, we extracted brain motor function regions from all brain as interesting region to analysis based on the generalized linear model analysis and the one-sample T-test model.From the figure of the brain activation, it can be seen that the differences between young group and old group in motor regions are not only in the volume of brain activation, but also in the strength of brain activation. Corresponding to the relationship between the anatomical location and functional areas, both young group and old group have the same parts of activated areas in motor function regions, including the primary motor area, the premotor contex, the supplementary motor area and the somatosensory motor area. Compared with young people, the number of activated volume in old people is decreased in the left primary motor area, the right premotor cortex, the right supplementary motor area and the somatosensory motor area, while increased in the left supplementary motor area and the right premotor cortex. And the activated intensity in the old people is enhanced in the left primary motor area, the bilateral premotor cortex, the left supplementary motor area and somatosensory motor area, while weakened in the right supplementary motor.Generally speaking, young people and old people activate a wide range of sports and world,for which reason it become very useful to our study. activated volume and activated intensity, which suggests that with the increasing of age, the decline of neuronal activity and the changes of structure, the original motor function areas may have mutual compensation and differentiation.
Keywords/Search Tags:Motor Function Area, Age, fMRI, Generalized Linear Model
PDF Full Text Request
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