Cd146 Expression In Sample Endometrial Adenocarcinoma And Its Clinical Significance

ObjectiveTo investigate the expression of microvessel density(MVD) of CD146positive microvessel in endometrioid adenocarcinoma,and the corelations between MVD and clinical pathological factors.MethodsUsing immunohistochemistry(SP) to evaluate the expression of CD146in46cases of endometrioid adenocarcinoma,26cases of normal endometrium and analysing MVD of CD146positive microvessel.ResultsThe average MVD of CD146positive microvessel in endometrioid adenocarcinoma were significantly higher than that in normal endometrium (P0.01),which is positively associated with tissue type,pathological stage (P0.01),and is not associated with age(P>0.05).ConclusionCD146is a positive indicator at invasion and metastasis of endometrioid adenocarcinoma.The expression level of CD146is positively related with the blood vessel’s formation in endometrioid adenocarcinoma development. ObjectiveTo investigate the expression of CD146protein in endometrioidadenocarcinoma.MethodsUsing Western Blotting to evaluate the expression of CD146protein in10cases of endometrioid adenocarcinoma,10cases ofnormal endometrium.ResultsThe expression level of CD146protein in endometrioidadenocarcinoma were significantly higher than that in normalendometrium (P＜0.05).ConclusionThe overexpression of CD146in endometrioid adenocarcinomasuggests that CD146is a positive indicator at invasion and metastasis of endometrioid adenocarcinoma.