Damp Heat Trapped In The Treatment Of Type 2 Diabetes With Puerariae And Scutellariae And Coptidis Decoction Spleen Syndrome Clinical Research

Type2diabetes (T2DM) is a complex genetic disease caused by m-ultiple genes and environmental factors, the world’s diabetes population of285mil lion, which accounted for90%of the total number of diabetes T2DM. Adults over the age of20diabetes prevalence was9.7%, and92.4million the total number of adults with diabetes. Diabetes has become a hazard to human heal th, the third serious major chronic non-communicable diseases, Gegenqinlian decoction in the treatment of diabetes have some clinical basis.Objective: To observe the Gegenqinlian decoction trapped type2diabetic patients (spleen impaired by wetness-heat) HbAlc standard-reaching rate, ob served by the before and after12weeks of medication, fasting glucose, pos tprandial blood glucose, insulin, blood lipids (cholesterol, triglycerides, LDL protein, high-density lipoprotein), BMI, waist circumference, hip circ umference, survival quality and mechanism of indicators of change, and safe ty of patients with type2diabetes in treating.Methods:The research is stratified random, double-blind, placebo-contro l1ed, multi-center clinical trial design, with a total time of14weeks, in eluding a2-week screening period and a12-week treatment period. Recruitme nt consistent with type2diabetes (damp-heat syndrome) diagnostic criteria for early onset of100cases, after a screening period of2weeks (diet+exercise therapy), into the observation period,100patients were randomly divided into the Gegen Qinlian group and comfort agent in the control group, treatment for12weeks. Patients receiving decoction200ml/packet,1pac ket/time,2times/day. Record screening period before the test,4weeks,8weeks,12weeks, blood glucose (fasting, postprandial2h), BMI, waist ci rcumference, hip circumference, traditional Chinese medicine syndrome and T CM symptoms of indicators; before the test, the test detected12weeks glyc osylated hemoglobin, blood lipids. Eventually enter the patients with FAS sets the statistical analysis.Results:included in the statistics in patients with a total of98case s in treatment group50cases,48cases in the control group, no significan t difference in baseline general information on the level of the main indie ators and TCM symptom score. After12weeks observation period, two groups of glycosylated hemoglobin and baseline decreased, a significant difference (P<0.05) compared with before treatment, a significant difference (P<0.05) between the two treatment groups, indicating the treatment group than p1acebo in improving glycosylated hemoglobin rate. Gegenqinlian decoction obv ious advantages in reducing glycosylated hemoglobin and blood sugar of type2diabetes have a good advantage, have a certain effect on the improvement of blood pressure, weight, waist and hip circumference, but general lifest yle intervention did not. Gegenqinlian decoction TCM symptom score in patie nts to improve the hot and humid Spleen certain effect, but no significant advantage compared with the control group. But a variety of single symptom improvement rate than the control group had a higher advantage.Conclusion: Gegenqinlian decoction in the treatment of type2diabetes patients (spleen impaired by wetness-heat) with good curative effect can be reduced in patients with glycosylated hemoglobin and blood sugar, and impr ove bad symptoms, have some protective effects on the cardiovascular syste m.